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- W2029574525 abstract "BackgroundDendritic cells (DCs) can act both as innate cells in host defense and as antigen-presenting cells for naive T cells in adaptive immunity. These functions, among others, are determined by the level of production of particular cytokines. Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by an initial phase predominated by TH2 cytokines that switches into a second, more chronic TH1-dominated eczematous phase.ObjectiveTo assess to what extent the AD phenotype is associated with an aberrant phenotype and function of DCs.MethodsClassic CD1c+/blood DC antigen (BDCA)–1+ myeloid (m) DCs and CD304+/BDCA4+ plasmacytoid (p) DCs, the natural IFN-producing cells, were isolated from peripheral blood of patients with AD and healthy controls and analyzed for their phenotype and function.ResultsPurified CD1c+/BDCA1+ mDCs from patients with AD showed a selective and dramatic reduction of IL-12p70 and TNF-α release. IL-12p70 reduction was attributed to a defective expression of both IL-12p35 and IL-12p40 subunits. Accordingly, mature CD1c+/BDCA1+ mDCs from patients with AD induced considerably less IFN-γ–producing and more IL-4–producing TH cells compared with mDCs from healthy controls. In addition, CD304+/BDCA4+ pDCs from patients with AD produced significantly lower levels of IFN-α compared with healthy controls.ConclusionMyeloid DCs and pDCs from patients with AD show defective IL-12, TNF-α, and IFN-α production, which may contribute to increased susceptibility to infection and to the maintenance of the TH2 cell–mediated allergic state in patients with AD. Dendritic cells (DCs) can act both as innate cells in host defense and as antigen-presenting cells for naive T cells in adaptive immunity. These functions, among others, are determined by the level of production of particular cytokines. Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by an initial phase predominated by TH2 cytokines that switches into a second, more chronic TH1-dominated eczematous phase. To assess to what extent the AD phenotype is associated with an aberrant phenotype and function of DCs. Classic CD1c+/blood DC antigen (BDCA)–1+ myeloid (m) DCs and CD304+/BDCA4+ plasmacytoid (p) DCs, the natural IFN-producing cells, were isolated from peripheral blood of patients with AD and healthy controls and analyzed for their phenotype and function. Purified CD1c+/BDCA1+ mDCs from patients with AD showed a selective and dramatic reduction of IL-12p70 and TNF-α release. IL-12p70 reduction was attributed to a defective expression of both IL-12p35 and IL-12p40 subunits. Accordingly, mature CD1c+/BDCA1+ mDCs from patients with AD induced considerably less IFN-γ–producing and more IL-4–producing TH cells compared with mDCs from healthy controls. In addition, CD304+/BDCA4+ pDCs from patients with AD produced significantly lower levels of IFN-α compared with healthy controls. Myeloid DCs and pDCs from patients with AD show defective IL-12, TNF-α, and IFN-α production, which may contribute to increased susceptibility to infection and to the maintenance of the TH2 cell–mediated allergic state in patients with AD." @default.
- W2029574525 created "2016-06-24" @default.
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- W2029574525 date "2008-11-01" @default.
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- W2029574525 title "Aberrant function of peripheral blood myeloid and plasmacytoid dendritic cells in atopic dermatitis patients" @default.
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- W2029574525 doi "https://doi.org/10.1016/j.jaci.2008.08.028" @default.
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