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• W2029589290 abstract "Human African Trypanosomiasis (HAT) is a severe, often fatal disease caused by the parasitic protist Trypanosoma brucei. The glycolytic pathway has been identified as the sole mechanism for ATP generation in the infective stage of these organisms, and several glycolytic enzymes, phosphofructokinase (PFK) in particular, have shown promise as potential drug targets. Herein, we describe the discovery of ML251, a novel nanomolar inhibitor of T. brucei PFK, and the structure–activity relationships within the series." @default.
• W2029589290 created "2016-06-24" @default.
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• W2029589290 date "2013-11-08" @default.
• W2029589290 modified "2023-10-12" @default.
• W2029589290 title "Identification of ML251, a Potent Inhibitor of <i>T. brucei and T. cruzi</i> Phosphofructokinase" @default.
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• W2029589290 doi "https://doi.org/10.1021/ml400259d" @default.
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