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- W2029591722 abstract "Objective To test the hypothesis that low concentrations of distal airspace water-soluble antioxidants are associated with acute lung injury. Design Prospective, cohort study. Setting Medical intensive care unit of two tertiary care hospitals. Subjects Subjects were 29 patients with acute lung injury and 23 normal, healthy, volunteers. Interventions None. Measurements and Main Results Pulmonary edema fluid from subjects with acute lung injury was aspirated immediately after intubation. Compared with the bronchoalveolar lavage from normal subjects (corrected for dilution using urea concentrations), undiluted edema fluid from acute lung injury subjects had significantly lower concentrations of the antioxidants urate (757 ± 232 μM vs. 328 ± 75 μM), glutathione (138 ± 25 μM vs. 7 ± 4 μM), and ascorbate (85 ± 21 μM vs. 27 ± 10 μM). Conclusions Acute lung injury is associated with decreased concentrations of water-soluble antioxidants in the distal airspaces. In acute lung injury, the distal airspace antioxidants ascorbate, urate, and glutathione may play a role in attenuating lung injury." @default.
- W2029591722 created "2016-06-24" @default.
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- W2029591722 date "2003-09-01" @default.
- W2029591722 modified "2023-10-03" @default.
- W2029591722 title "Pulmonary edema fluid antioxidants are depressed in acute lung injury" @default.
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- W2029591722 doi "https://doi.org/10.1097/01.ccm.0000085090.06078.8c" @default.
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