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• W2029591858 abstract "Since more than 40% of today's drugs have low stability, poor solubility and/or limited ability to cross certain biological barriers, new platform technologies are required to address these challenges. This paper describes a novel continuous process that converts a stabilized aqueous nano-suspension into a solid oral formulation in a single step (i.e., the NANEX process) in order to improve the solubility of a model drug (phenytoin). Phenytoin nano-suspensions were prepared via media milling using different stabilizers. A stable nano-suspension was obtained using Tween(®) 80 as a stabilizer. The matrix material (Soluplus(®)) was gravimetrically fed into the hot melt extruder. The suspension was introduced through a side feeding device and mixed with the molten polymer to immediately devolatilize the water in the nano-suspension. Phenytoin nano-crystals were dispersed and embedded in the molten polymer. Investigation of the nano-extrudates via transmission electron microscopy and atomic force microscopy showed that the nano-crystals were embedded de-aggregated in the extrudates. Furthermore, no changes in the crystallinity (due to the mechanical and thermal stress) occurred. The dissolution studies confirmed that the prepared nano-extrudates increased the solubility of nano-crystalline phenytoin, regardless of the polymer. Our work demonstrates that NANEX represents a promising new platform technology in the design of novel drug delivery systems to improve drug performance." @default.
• W2029591858 created "2016-06-24" @default.
• W2029591858 creator A5014511802 @default.
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• W2029591858 date "2014-12-01" @default.
• W2029591858 modified "2023-09-26" @default.
• W2029591858 title "Nano-extrusion: A promising tool for continuous manufacturing of solid nano-formulations" @default.
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• W2029591858 doi "https://doi.org/10.1016/j.ijpharm.2014.10.008" @default.
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• W2029591858 hasPublicationYear "2014" @default.
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