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- W2029592008 abstract "The aim of present study was to evaluate the qualities of chaste berry (fruit of Vitex agnus-castus L.) preparations using HPLC fingerprint analysis. Seven medicinal products 1 from Japan and 6 from Europe, and 17 health foods, 6 from Japan and 11 from the United States were analyzed. HPLC profile and 26 authentic peaks were compared medicinal products and health foods. Whereas medicinal products had similar HPLC profiles, health foods had various profiles and each peak was also greatly different. The measured amounts of two markers in 5 traditional medicinal products, agnuside and casticin specified in the European Pharmacopoeia (EP), the U.S. Pharmacopoeia (USP) or the WHO monographs of chaste berry, were much lower than those in 2 medicinal products defined as “well-established use” by the European Medicines Agency. The amounts of two markers for 17 health foods differed in a great deal from 14–5054% and 3–1272%, respectively. Furthermore the amount ratios of two markers, agnuside/casticin, in about half of the health foods were remarkably larger than the standard crude drug and the ratios were closer to one of the related Chinese herbs, Vitex negundo L. It is concluded that a combination of HPLC fingerprints and the amount ratios of the marker compounds of chaste berry preparations serves as a useful tool to evaluate the qualities of these preparations." @default.
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- W2029592008 date "2014-01-01" @default.
- W2029592008 modified "2023-10-02" @default.
- W2029592008 title "Quality Evaluation of Medicinal Products and Health Foods Containing Chaste Berry (<i>Vitex agnus-castus</i>) in Japanese, European and American Markets" @default.
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- W2029592008 doi "https://doi.org/10.1248/cpb.c13-00588" @default.
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