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• W2029592813 abstract "Functional pial vessels denuded in situ of the endothelial cell layer exhibit a markedly decreased choline uptake capacity (-53%) but integrally preserved choline acetyltransferase (ChAT) activity and acetylcholine (ACh) release mechanisms. These studies demonstrate that endothelial cells possess a specific choline uptake system. However, the unimpaired ChAT activity in denuded pial vessels implies that the endothelial pool of choline is not significantly metabolized into ACh. In spite of possible differences in the mechanisms that govern release processes in endothelial and neuronal elements, taken together the findings of the present study suggest that the ACh released following depolarization of pial blood vessels originates predominantly from cholinergic perivascular nerve terminals." @default.
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• W2029592813 date "1987-09-01" @default.
• W2029592813 modified "2023-09-23" @default.
• W2029592813 title "Neuronal versus endothelial origin of vasoactive acetylcholine in pial vessels" @default.
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• W2029592813 doi "https://doi.org/10.1016/0006-8993(87)91263-7" @default.
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