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- W2029593022 abstract "A case of diffuse large cell lymphoma with t(2p−;8q+) is reported. Immunologically the lymphoma cells were shown to be of B-cell origin and positive for surface γ and κ chains, B4, CALLA, and Ia1 markers. Karyotypically three major clones were detected: 47,XX,+12,t(2;8)(p11–13;q24) (52%); 47,XX,+12 (26%); and 46,XX,t(2;8)(p11–13;q24) (15%). A t(2p−;8q+) has been exclusively reported in cases of Burkitt's lymphoma or Burkitt-type acute lymphocytic leukemia. The present case is the first one with t(2p−;8q+) observed in non-Burkitt-type lymphoid malignancy of the B-cell lineage. The t(2p−;8q+) may play a primary role in the early stage of transformation of B cells, and trisomy 12 may provide them secondarily with an advantage for tumor progression. The phenotypic pictures provided by 8q24 rearrangements seem to be heterogeneous, as previously suggested." @default.
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- W2029593022 date "1987-02-01" @default.
- W2029593022 modified "2023-09-23" @default.
- W2029593022 title "A variant Burkitt-type translocation (2p−;8q+) in a patient with diffuse large cell lymphoma" @default.
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- W2029593022 doi "https://doi.org/10.1016/0165-4608(87)90103-8" @default.
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