FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029593639> ?p ?o ?g. }

• W2029593639 endingPage "589" @default.
• W2029593639 startingPage "584" @default.
• W2029593639 abstract "Esophageal squamous cell carcinoma (ESCC) is highly fatal due to late diagnosis and inefficient treatment. Early disease detection could improve diagnosis and patient survival. Esophageal squamous epithelial cells express SPRR3, a member of the small proline-rich protein family, which is downregulated in ESCC. Therefore, SPRR3 expression may be used as a biomarker to follow the transition from healthy mucosa to ESCC. Both SPRR3 mRNA splice variants, v1 and v2, were evaluated by real time PCR in tumor and histologically normal adjacent tissue biopsies from 84 ESCC patients and 18 healthy controls. SPRR3-v1 was most highly expressed in the esophageal mucosa of healthy subjects, with an increasingly lower expression in the adjacent mucosa of ESCC patients and in tumors, respectively. SPRR3-v2 expression was low in normal mucosa and in tumors but it was higher in the adjacent mucosa of ESCC patients. In addition, we found a significant correlation between a lower SPRR3-v1 and SPRR3-v2 expression and age and alcohol consumption, respectively. SPRR3 protein expression presented a good correlation with SPRR3 mRNA expression. Cut-off points to discriminate between healthy mucosa, tumor and adjacent mucosa were determined with receiver operating characteristic (ROC) curves. This analysis showed that SPRR3-v1 expression discriminates the esophageal mucosa of healthy subjects from the adjacent mucosa and the tumor of ESCC patients with high sensitivity and specificity. Our data shows that the quantitative analysis of SPRR3 mRNA is a robust and reliable method to monitor the malignant transformation of the healthy esophageal mucosa into ESCC." @default.
• W2029593639 created "2016-06-24" @default.
• W2029593639 creator A5008755171 @default.
• W2029593639 creator A5017102483 @default.
• W2029593639 creator A5030267916 @default.
• W2029593639 creator A5030967291 @default.
• W2029593639 creator A5039530981 @default.
• W2029593639 creator A5044947102 @default.
• W2029593639 creator A5047504817 @default.
• W2029593639 creator A5061090879 @default.
• W2029593639 creator A5066697535 @default.
• W2029593639 creator A5078548377 @default.
• W2029593639 date "2011-10-01" @default.
• W2029593639 modified "2023-10-17" @default.
• W2029593639 title "Quantitative evaluation of SPRR3 expression in esophageal squamous cell carcinoma by qPCR and its potential use as a biomarker" @default.
• W2029593639 cites W1495655723 @default.
• W2029593639 cites W1966342654 @default.
• W2029593639 cites W1971771465 @default.
• W2029593639 cites W1972549014 @default.
• W2029593639 cites W1973589866 @default.
• W2029593639 cites W1975165380 @default.
• W2029593639 cites W1977463937 @default.
• W2029593639 cites W1977483712 @default.
• W2029593639 cites W1991949008 @default.
• W2029593639 cites W1995232510 @default.
• W2029593639 cites W2003161283 @default.
• W2029593639 cites W2005630031 @default.
• W2029593639 cites W2019576452 @default.
• W2029593639 cites W2020830322 @default.
• W2029593639 cites W2022143952 @default.
• W2029593639 cites W2023082982 @default.
• W2029593639 cites W2027234544 @default.
• W2029593639 cites W2034303744 @default.
• W2029593639 cites W2048497033 @default.
• W2029593639 cites W2052899135 @default.
• W2029593639 cites W2058207576 @default.
• W2029593639 cites W2062812764 @default.
• W2029593639 cites W2088013507 @default.
• W2029593639 cites W2088109423 @default.
• W2029593639 cites W2088461277 @default.
• W2029593639 cites W2093658093 @default.
• W2029593639 cites W2094315259 @default.
• W2029593639 cites W2095295468 @default.
• W2029593639 cites W2120244810 @default.
• W2029593639 cites W2133463872 @default.
• W2029593639 cites W2141477873 @default.
• W2029593639 cites W2144709254 @default.
• W2029593639 cites W2145998512 @default.
• W2029593639 cites W2162690794 @default.
• W2029593639 cites W2311845087 @default.
• W2029593639 doi "https://doi.org/10.1016/j.yexmp.2011.06.006" @default.
• W2029593639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21777580" @default.
• W2029593639 hasPublicationYear "2011" @default.
• W2029593639 type Work @default.
• W2029593639 sameAs 2029593639 @default.
• W2029593639 citedByCount "20" @default.
• W2029593639 countsByYear W20295936392012 @default.
• W2029593639 countsByYear W20295936392013 @default.
• W2029593639 countsByYear W20295936392015 @default.
• W2029593639 countsByYear W20295936392016 @default.
• W2029593639 countsByYear W20295936392017 @default.
• W2029593639 countsByYear W20295936392018 @default.
• W2029593639 countsByYear W20295936392020 @default.
• W2029593639 countsByYear W20295936392021 @default.
• W2029593639 countsByYear W20295936392022 @default.
• W2029593639 countsByYear W20295936392023 @default.
• W2029593639 crossrefType "journal-article" @default.
• W2029593639 hasAuthorship W2029593639A5008755171 @default.
• W2029593639 hasAuthorship W2029593639A5017102483 @default.
• W2029593639 hasAuthorship W2029593639A5030267916 @default.
• W2029593639 hasAuthorship W2029593639A5030967291 @default.
• W2029593639 hasAuthorship W2029593639A5039530981 @default.
• W2029593639 hasAuthorship W2029593639A5044947102 @default.
• W2029593639 hasAuthorship W2029593639A5047504817 @default.
• W2029593639 hasAuthorship W2029593639A5061090879 @default.
• W2029593639 hasAuthorship W2029593639A5066697535 @default.
• W2029593639 hasAuthorship W2029593639A5078548377 @default.
• W2029593639 hasConcept C126322002 @default.
• W2029593639 hasConcept C142724271 @default.
• W2029593639 hasConcept C2777546739 @default.
• W2029593639 hasConcept C2781197716 @default.
• W2029593639 hasConcept C2994415158 @default.
• W2029593639 hasConcept C3019368612 @default.
• W2029593639 hasConcept C502942594 @default.
• W2029593639 hasConcept C55493867 @default.
• W2029593639 hasConcept C58471807 @default.
• W2029593639 hasConcept C71924100 @default.
• W2029593639 hasConcept C86803240 @default.
• W2029593639 hasConceptScore W2029593639C126322002 @default.
• W2029593639 hasConceptScore W2029593639C142724271 @default.
• W2029593639 hasConceptScore W2029593639C2777546739 @default.
• W2029593639 hasConceptScore W2029593639C2781197716 @default.
• W2029593639 hasConceptScore W2029593639C2994415158 @default.
• W2029593639 hasConceptScore W2029593639C3019368612 @default.
• W2029593639 hasConceptScore W2029593639C502942594 @default.
• W2029593639 hasConceptScore W2029593639C55493867 @default.
• W2029593639 hasConceptScore W2029593639C58471807 @default.
• W2029593639 hasConceptScore W2029593639C71924100 @default.

• next