Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029593703> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2029593703 endingPage "127" @default.
- W2029593703 startingPage "121" @default.
- W2029593703 abstract "1 Prostacyclin and its stable analogue, carbacyclin, bind competitively to a single population of receptors, and activate adenylate cyclase of the NCB-20 neuronal somatic cell hybrid (Kact = 40.1 nM and 96.1 nM respectively). 2 Culture of NCB-20 cells in the presence of 1 μm carbacyclin for 4 to 16 h results in a progressive decrease in the prostacyclin-dependent activation of adenylate cyclase in cell homogenates with an increase at 16 h of the Kact from 64.1 nm to 174.0 nm and decrease in the maximum adenylate cyclase activation from 41.2 to 15.1 pmol cyclic AMP min−1 mg−1 protein. 3 The prediction that the apparent decrease in affinity in the prostacyclin-dependent activation of adenylate cyclase was secondary to a reduction in receptor numbers was tested directly by measuring binding of [3H]-prostacyclin to membranes of cells exposed to carbacyclin for 16 h. This showed an actual decrease in affinity of the prostacyclin-receptor interaction, as well as a decrease in the total receptor numbers. Thus prolonged exposure of NCB-20 cells to carbacyclin caused reductions in both receptor numbers and affinity, reflected by measurements both of binding and adenylate cyclase activation." @default.
- W2029593703 created "2016-06-24" @default.
- W2029593703 creator A5034566838 @default.
- W2029593703 creator A5066928485 @default.
- W2029593703 creator A5079384190 @default.
- W2029593703 date "1982-09-01" @default.
- W2029593703 modified "2023-09-26" @default.
- W2029593703 title "DESENSITIZATION OF PROSTACYCLIN RECEPTORS IN A NEURONAL HYBRID CELL LINE" @default.
- W2029593703 cites W129838049 @default.
- W2029593703 cites W1561372395 @default.
- W2029593703 cites W1571192847 @default.
- W2029593703 cites W171519394 @default.
- W2029593703 cites W1775749144 @default.
- W2029593703 cites W1964733226 @default.
- W2029593703 cites W1977275887 @default.
- W2029593703 cites W1978890501 @default.
- W2029593703 cites W1991471287 @default.
- W2029593703 cites W1992076316 @default.
- W2029593703 cites W1993097923 @default.
- W2029593703 cites W2000125000 @default.
- W2029593703 cites W2002630172 @default.
- W2029593703 cites W2010291027 @default.
- W2029593703 cites W2018242346 @default.
- W2029593703 cites W2029134608 @default.
- W2029593703 cites W2037444729 @default.
- W2029593703 cites W2044692997 @default.
- W2029593703 cites W2057591548 @default.
- W2029593703 cites W2062185761 @default.
- W2029593703 cites W2075156914 @default.
- W2029593703 cites W2075676530 @default.
- W2029593703 cites W2080366043 @default.
- W2029593703 cites W2091407448 @default.
- W2029593703 cites W2111890100 @default.
- W2029593703 cites W2169503005 @default.
- W2029593703 cites W2413483194 @default.
- W2029593703 cites W2413586617 @default.
- W2029593703 cites W2433220585 @default.
- W2029593703 doi "https://doi.org/10.1111/j.1476-5381.1982.tb09277.x" @default.
- W2029593703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2044635" @default.
- W2029593703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6289953" @default.
- W2029593703 hasPublicationYear "1982" @default.
- W2029593703 type Work @default.
- W2029593703 sameAs 2029593703 @default.
- W2029593703 citedByCount "16" @default.
- W2029593703 crossrefType "journal-article" @default.
- W2029593703 hasAuthorship W2029593703A5034566838 @default.
- W2029593703 hasAuthorship W2029593703A5066928485 @default.
- W2029593703 hasAuthorship W2029593703A5079384190 @default.
- W2029593703 hasBestOaLocation W20295937032 @default.
- W2029593703 hasConcept C12554922 @default.
- W2029593703 hasConcept C126322002 @default.
- W2029593703 hasConcept C134018914 @default.
- W2029593703 hasConcept C170493617 @default.
- W2029593703 hasConcept C180526460 @default.
- W2029593703 hasConcept C185592680 @default.
- W2029593703 hasConcept C2779779143 @default.
- W2029593703 hasConcept C2780069284 @default.
- W2029593703 hasConcept C2781128415 @default.
- W2029593703 hasConcept C55493867 @default.
- W2029593703 hasConcept C71924100 @default.
- W2029593703 hasConcept C86803240 @default.
- W2029593703 hasConceptScore W2029593703C12554922 @default.
- W2029593703 hasConceptScore W2029593703C126322002 @default.
- W2029593703 hasConceptScore W2029593703C134018914 @default.
- W2029593703 hasConceptScore W2029593703C170493617 @default.
- W2029593703 hasConceptScore W2029593703C180526460 @default.
- W2029593703 hasConceptScore W2029593703C185592680 @default.
- W2029593703 hasConceptScore W2029593703C2779779143 @default.
- W2029593703 hasConceptScore W2029593703C2780069284 @default.
- W2029593703 hasConceptScore W2029593703C2781128415 @default.
- W2029593703 hasConceptScore W2029593703C55493867 @default.
- W2029593703 hasConceptScore W2029593703C71924100 @default.
- W2029593703 hasConceptScore W2029593703C86803240 @default.
- W2029593703 hasIssue "1" @default.
- W2029593703 hasLocation W20295937031 @default.
- W2029593703 hasLocation W20295937032 @default.
- W2029593703 hasLocation W20295937033 @default.
- W2029593703 hasLocation W20295937034 @default.
- W2029593703 hasOpenAccess W2029593703 @default.
- W2029593703 hasPrimaryLocation W20295937031 @default.
- W2029593703 hasRelatedWork W1978419663 @default.
- W2029593703 hasRelatedWork W2019744095 @default.
- W2029593703 hasRelatedWork W2025626785 @default.
- W2029593703 hasRelatedWork W2027266387 @default.
- W2029593703 hasRelatedWork W2029369136 @default.
- W2029593703 hasRelatedWork W2056306087 @default.
- W2029593703 hasRelatedWork W2077205476 @default.
- W2029593703 hasRelatedWork W2155585839 @default.
- W2029593703 hasRelatedWork W2159228864 @default.
- W2029593703 hasRelatedWork W2398181117 @default.
- W2029593703 hasVolume "77" @default.
- W2029593703 isParatext "false" @default.
- W2029593703 isRetracted "false" @default.
- W2029593703 magId "2029593703" @default.
- W2029593703 workType "article" @default.