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• W2029605093 abstract "The phenotypes of mice carrying clock gene mutations have been critical to understanding the mammalian clock function. However, behavior does not necessarily reflect cell-autonomous clock phenotypes, because of the hierarchical dominance of the central clock. We performed cell-based siRNA knockdown and cDNA overexpression and monitored rhythm using bioluminescent reporters of clock genes. We found that knockdown of DBP, D-box positive regulator, in our model led to a short-period phenotype, whereas overexpressing of DBP produced a long-period rhythm when compared to controls. Furthermore, knockdown and overexpressing of E4BP4, D-box negative regulator, led to an opposite effect of DBP. Our experiments demonstrated that D-box regulators play a crucial role in determining the period length of Per1 and Per2 promoter-driven circadian rhythms in Rat-1 fibroblasts." @default.
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• W2029605093 date "2011-05-27" @default.
• W2029605093 modified "2023-09-24" @default.
• W2029605093 title "Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator" @default.
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• W2029605093 doi "https://doi.org/10.1016/j.febslet.2011.05.038" @default.
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