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• W2029607351 abstract "Primary chick embryo forebrain culture was examined with respect to its usefulness as a model to study organophosphate (OP) anticholinesterases. The acetylcholinesterase (AChE) activity of these cultures increased with time in culture and paralleled the development in ovo of this enzyme. The neuronal cells were extremely sensitive to the anticholinesterase effects of OP nerve agents, and experiments with soman indicated that enzyme inhibition was rapid and persistent. The potencies of several OP nerve agents as inhibitors of AChE activity in vitro paralleled their literature-reported toxicities in vivo." @default.
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• W2029607351 date "1992-05-01" @default.
• W2029607351 modified "2023-09-27" @default.
• W2029607351 title "Anticholinesterase activity of organophosphate nerve agents in neuronal tissue culture" @default.
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• W2029607351 doi "https://doi.org/10.1016/0887-2333(92)90040-x" @default.
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