Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029607675> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2029607675 endingPage "49" @default.
- W2029607675 startingPage "317" @default.
- W2029607675 abstract "Interferon (IFN)-gamma is a cytokine produced mostly by activated T cells and NK cells that has complex effects on immune and nonimmune cells. IFN-gamma plays important roles in inflammation, usually in synergy with other cytokines, such as IL-1beta and TNF-alpha. The uniqueness of IFN-gamma lies in its ability to induce major histocompatibility complex (MHC) expression in many tissues, making it particularly relevant to transplantation. The results of graft rejection in the absence of IFN-gamma show that IFN-gamma modulates but is not essential for the allogeneic responses, suppressing generation of CTL. In vivo IFN-gamma has a protective role early in the response to vascularized organ allografts: transplants in mice have a tendency to develop necrosis when IFN-gamma is not available, apparently by failure of the microcirculation. The lack of IFN-gamma greatly reduces the induction of MHC in organ allografts, and it is possible that this is indirectly related to the protective effect of IFN-gamma. Nevertheless IFN-gamma also promotes graft vessel disease later in the course ofthe transplant. Thus IFN-gamma has diverse and potentially contradictory effects on organ allograft survival, acting both on the immune system and on the graft itself, the net effect depending on the graft type and the time post-transplant." @default.
- W2029607675 created "2016-06-24" @default.
- W2029607675 creator A5072478271 @default.
- W2029607675 creator A5078233658 @default.
- W2029607675 date "2002-01-01" @default.
- W2029607675 modified "2023-10-06" @default.
- W2029607675 title "Role of IFN-gamma in allograft rejection." @default.
- W2029607675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12678431" @default.
- W2029607675 hasPublicationYear "2002" @default.
- W2029607675 type Work @default.
- W2029607675 sameAs 2029607675 @default.
- W2029607675 citedByCount "28" @default.
- W2029607675 countsByYear W20296076752013 @default.
- W2029607675 countsByYear W20296076752014 @default.
- W2029607675 countsByYear W20296076752015 @default.
- W2029607675 countsByYear W20296076752017 @default.
- W2029607675 countsByYear W20296076752021 @default.
- W2029607675 countsByYear W20296076752022 @default.
- W2029607675 countsByYear W20296076752023 @default.
- W2029607675 crossrefType "journal-article" @default.
- W2029607675 hasAuthorship W2029607675A5072478271 @default.
- W2029607675 hasAuthorship W2029607675A5078233658 @default.
- W2029607675 hasConcept C126322002 @default.
- W2029607675 hasConcept C147969180 @default.
- W2029607675 hasConcept C167672396 @default.
- W2029607675 hasConcept C203014093 @default.
- W2029607675 hasConcept C207936829 @default.
- W2029607675 hasConcept C2776914184 @default.
- W2029607675 hasConcept C2778690821 @default.
- W2029607675 hasConcept C2780841837 @default.
- W2029607675 hasConcept C2911091166 @default.
- W2029607675 hasConcept C71924100 @default.
- W2029607675 hasConcept C86803240 @default.
- W2029607675 hasConcept C8891405 @default.
- W2029607675 hasConceptScore W2029607675C126322002 @default.
- W2029607675 hasConceptScore W2029607675C147969180 @default.
- W2029607675 hasConceptScore W2029607675C167672396 @default.
- W2029607675 hasConceptScore W2029607675C203014093 @default.
- W2029607675 hasConceptScore W2029607675C207936829 @default.
- W2029607675 hasConceptScore W2029607675C2776914184 @default.
- W2029607675 hasConceptScore W2029607675C2778690821 @default.
- W2029607675 hasConceptScore W2029607675C2780841837 @default.
- W2029607675 hasConceptScore W2029607675C2911091166 @default.
- W2029607675 hasConceptScore W2029607675C71924100 @default.
- W2029607675 hasConceptScore W2029607675C86803240 @default.
- W2029607675 hasConceptScore W2029607675C8891405 @default.
- W2029607675 hasIssue "4" @default.
- W2029607675 hasLocation W20296076751 @default.
- W2029607675 hasOpenAccess W2029607675 @default.
- W2029607675 hasPrimaryLocation W20296076751 @default.
- W2029607675 hasRelatedWork W141088424 @default.
- W2029607675 hasRelatedWork W1557621914 @default.
- W2029607675 hasRelatedWork W2034633641 @default.
- W2029607675 hasRelatedWork W2047209980 @default.
- W2029607675 hasRelatedWork W2069114398 @default.
- W2029607675 hasRelatedWork W2070073485 @default.
- W2029607675 hasRelatedWork W2162888910 @default.
- W2029607675 hasRelatedWork W2401861985 @default.
- W2029607675 hasRelatedWork W3136031961 @default.
- W2029607675 hasRelatedWork W2185732136 @default.
- W2029607675 hasVolume "22" @default.
- W2029607675 isParatext "false" @default.
- W2029607675 isRetracted "false" @default.
- W2029607675 magId "2029607675" @default.
- W2029607675 workType "article" @default.