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• W2029609355 abstract "Beta frequency (13–30 Hz) oscillatory activity in the subthalamic nucleus (STN) of Parkinson9s disease (PD) has been shown to influence the temporal dynamics of high-frequency oscillations (HFOs; 200–500 Hz) and single neurons, potentially compromising the functional flexibility of the motor circuit. We examined these interactions by simultaneously recording both local field potential and single-unit activity from the basal ganglia of 15 patients with PD during deep brain stimulation (DBS) surgery of the bilateral STN. Phase-amplitude coupling (PAC) in the STN was specific to beta phase and HFO amplitude, and this coupling was strongest at the dorsal STN border. We found higher beta-HFO PAC near DBS lead contacts that were clinically effective compared with the remaining non-effective contacts, indicating that PAC may be predictive of response to STN DBS. Neuronal spiking was locked to the phase of 8–30 Hz oscillations, and the spatial topography of spike-phase locking (SPL) was similar to that of PAC. Comparisons of PAC and SPL showed a lack of spatiotemporal correlations. Beta-coupled HFOs and field-locked neurons had different preferred phase angles and did not co-occur within the same cycle of the modulating oscillation. Our findings provide additional support that beta-HFO PAC may be central to the pathophysiology of PD and suggest that field-locked neurons alone are not sufficient for the emergence of beta-coupled HFOs." @default.
• W2029609355 created "2016-06-24" @default.
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• W2029609355 date "2014-09-17" @default.
• W2029609355 modified "2023-09-28" @default.
• W2029609355 title "Beta-Coupled High-Frequency Activity and Beta-Locked Neuronal Spiking in the Subthalamic Nucleus of Parkinson's Disease" @default.
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• W2029609355 doi "https://doi.org/10.1523/jneurosci.1895-14.2014" @default.
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