FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029609917> ?p ?o ?g. }

• W2029609917 endingPage "2025" @default.
• W2029609917 startingPage "2022" @default.
• W2029609917 abstract "The serotonin1A receptor is an important member of the G-protein coupled receptor family, and is involved in the generation and modulation of a variety of cognitive, behavioral, and developmental functions. We have monitored the ligand binding of the human serotonin1A receptor stably expressed in CHO cells (termed CHO-5-HT1AR) following treatment with sphingomyelinase (SMase), an enzyme that specifically catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine. Our results show, for the first time, that the specific ligand binding activity of the serotonin1A receptor in membranes isolated from CHO-5-HT1AR cells is increased upon sphingomyelinase treatment. Saturation binding analysis reveals increase in binding affinity of the receptor under these conditions. This is accompanied by a reduction in membrane order, as monitored by fluorescence anisotropy of the membrane probe 1-[4-(trimethylammonio)phenyl]-6-phenyl-1,3,5-hexatriene (TMA-DPH) in intact cells. These results represent the first report on the effect of sphingomyelinase treatment on the ligand binding activity of this important neurotransmitter receptor." @default.
• W2029609917 created "2016-06-24" @default.
• W2029609917 creator A5047952576 @default.
• W2029609917 creator A5050190785 @default.
• W2029609917 creator A5063835467 @default.
• W2029609917 date "2008-10-01" @default.
• W2029609917 modified "2023-10-13" @default.
• W2029609917 title "Effect of sphingomyelinase treatment on ligand binding activity of human serotonin1A receptors" @default.
• W2029609917 cites W1914926542 @default.
• W2029609917 cites W1917834902 @default.
• W2029609917 cites W194181531 @default.
• W2029609917 cites W1969158591 @default.
• W2029609917 cites W1987970138 @default.
• W2029609917 cites W1991079346 @default.
• W2029609917 cites W1992963529 @default.
• W2029609917 cites W1994702289 @default.
• W2029609917 cites W1995194976 @default.
• W2029609917 cites W1997373967 @default.
• W2029609917 cites W2003474943 @default.
• W2029609917 cites W2007109865 @default.
• W2029609917 cites W2019696898 @default.
• W2029609917 cites W2033677065 @default.
• W2029609917 cites W2038702871 @default.
• W2029609917 cites W2047119159 @default.
• W2029609917 cites W2048410358 @default.
• W2029609917 cites W2064744580 @default.
• W2029609917 cites W2072578069 @default.
• W2029609917 cites W2076710424 @default.
• W2029609917 cites W2078926268 @default.
• W2029609917 cites W2085246663 @default.
• W2029609917 cites W2088426105 @default.
• W2029609917 cites W2089880141 @default.
• W2029609917 cites W2094622306 @default.
• W2029609917 cites W2110979251 @default.
• W2029609917 cites W2114565306 @default.
• W2029609917 cites W2120204888 @default.
• W2029609917 cites W2138505417 @default.
• W2029609917 cites W2300552860 @default.
• W2029609917 cites W4232534952 @default.
• W2029609917 doi "https://doi.org/10.1016/j.bbamem.2008.07.007" @default.
• W2029609917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18675780" @default.
• W2029609917 hasPublicationYear "2008" @default.
• W2029609917 type Work @default.
• W2029609917 sameAs 2029609917 @default.
• W2029609917 citedByCount "35" @default.
• W2029609917 countsByYear W20296099172012 @default.
• W2029609917 countsByYear W20296099172013 @default.
• W2029609917 countsByYear W20296099172014 @default.
• W2029609917 countsByYear W20296099172015 @default.
• W2029609917 countsByYear W20296099172016 @default.
• W2029609917 countsByYear W20296099172017 @default.
• W2029609917 countsByYear W20296099172018 @default.
• W2029609917 countsByYear W20296099172019 @default.
• W2029609917 countsByYear W20296099172020 @default.
• W2029609917 countsByYear W20296099172021 @default.
• W2029609917 countsByYear W20296099172022 @default.
• W2029609917 crossrefType "journal-article" @default.
• W2029609917 hasAuthorship W2029609917A5047952576 @default.
• W2029609917 hasAuthorship W2029609917A5050190785 @default.
• W2029609917 hasAuthorship W2029609917A5063835467 @default.
• W2029609917 hasBestOaLocation W20296099171 @default.
• W2029609917 hasConcept C116569031 @default.
• W2029609917 hasConcept C12554922 @default.
• W2029609917 hasConcept C170493617 @default.
• W2029609917 hasConcept C185592680 @default.
• W2029609917 hasConcept C190283241 @default.
• W2029609917 hasConcept C2776833585 @default.
• W2029609917 hasConcept C2777851122 @default.
• W2029609917 hasConcept C41625074 @default.
• W2029609917 hasConcept C55493867 @default.
• W2029609917 hasConcept C61322309 @default.
• W2029609917 hasConcept C86803240 @default.
• W2029609917 hasConcept C95444343 @default.
• W2029609917 hasConceptScore W2029609917C116569031 @default.
• W2029609917 hasConceptScore W2029609917C12554922 @default.
• W2029609917 hasConceptScore W2029609917C170493617 @default.
• W2029609917 hasConceptScore W2029609917C185592680 @default.
• W2029609917 hasConceptScore W2029609917C190283241 @default.
• W2029609917 hasConceptScore W2029609917C2776833585 @default.
• W2029609917 hasConceptScore W2029609917C2777851122 @default.
• W2029609917 hasConceptScore W2029609917C41625074 @default.
• W2029609917 hasConceptScore W2029609917C55493867 @default.
• W2029609917 hasConceptScore W2029609917C61322309 @default.
• W2029609917 hasConceptScore W2029609917C86803240 @default.
• W2029609917 hasConceptScore W2029609917C95444343 @default.
• W2029609917 hasIssue "10" @default.
• W2029609917 hasLocation W20296099171 @default.
• W2029609917 hasLocation W20296099172 @default.
• W2029609917 hasOpenAccess W2029609917 @default.
• W2029609917 hasPrimaryLocation W20296099171 @default.
• W2029609917 hasRelatedWork W2015787318 @default.
• W2029609917 hasRelatedWork W2039122956 @default.
• W2029609917 hasRelatedWork W2039904623 @default.
• W2029609917 hasRelatedWork W2053891202 @default.
• W2029609917 hasRelatedWork W2088001693 @default.
• W2029609917 hasRelatedWork W2119623639 @default.
• W2029609917 hasRelatedWork W2331927553 @default.
• W2029609917 hasRelatedWork W2405311999 @default.

• next