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- W2029614557 abstract "The antrum is the richest source of gastrin. G-cell hyperplasia is found among hypochlorydric patients with atrophic gastritis. Only a slightly decreased fasting serum gastrin level is found in postgastrectomy patients, despite of having their antrum removed. Aim:To investigate gastrin immunoexpression in postgastrectomy mucosa and proximal jejunum. Methods: 176 endoscopic biopsies from eight sites of 22 postgastrectomy patients for benign disease with Billroth II reconstruction, 15-47 (mean=28.3) years following partial gastrectomy were evaluated. Immunohistochemical analysis of gastrin was performed on formalin fixed, paraffin embedded tissue using the avidin-biotin-peroxidade complex method. Results: In the controls, all cells positive for gastrin stained vividly, whereas stump biopsies specimens demonstrated cells with brown cytoplasmic staining scarcely distributed in the glands. Gastrin immunoexpression was observed in 17/154 (11.03%) of the gastric biopsies and in 9/22 (40.9%) of the patients. All jejunum biopsies (n= 22) revealed a strong reactivity, preferentially at the basal layer of the epithelia. There was no association between gastrin expression and the presence of Helicobacter pylori, cystic dilation, atrophy, intestinal metaplasia and dysplasia in the gastric stump. Conclusion: Immunoexpression of gastrin in the proximal jejunum and in the gastric stump may explain the serum gastrin level in postgastrectomy patients. The antrum is the richest source of gastrin. G-cell hyperplasia is found among hypochlorydric patients with atrophic gastritis. Only a slightly decreased fasting serum gastrin level is found in postgastrectomy patients, despite of having their antrum removed. Aim:To investigate gastrin immunoexpression in postgastrectomy mucosa and proximal jejunum. Methods: 176 endoscopic biopsies from eight sites of 22 postgastrectomy patients for benign disease with Billroth II reconstruction, 15-47 (mean=28.3) years following partial gastrectomy were evaluated. Immunohistochemical analysis of gastrin was performed on formalin fixed, paraffin embedded tissue using the avidin-biotin-peroxidade complex method. Results: In the controls, all cells positive for gastrin stained vividly, whereas stump biopsies specimens demonstrated cells with brown cytoplasmic staining scarcely distributed in the glands. Gastrin immunoexpression was observed in 17/154 (11.03%) of the gastric biopsies and in 9/22 (40.9%) of the patients. All jejunum biopsies (n= 22) revealed a strong reactivity, preferentially at the basal layer of the epithelia. There was no association between gastrin expression and the presence of Helicobacter pylori, cystic dilation, atrophy, intestinal metaplasia and dysplasia in the gastric stump. Conclusion: Immunoexpression of gastrin in the proximal jejunum and in the gastric stump may explain the serum gastrin level in postgastrectomy patients." @default.
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- W2029614557 date "2000-04-01" @default.
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- W2029614557 title "4758 Gastrin is expressed in jejunum biopsies of postgastrectomy patients." @default.
- W2029614557 doi "https://doi.org/10.1016/s0016-5107(00)14605-x" @default.
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