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- W2029619889 abstract "Early infection with HIV-1 is dominated by CCR5-tropic (R5, non-syncytium-inducing) viruses. The evolution of CXCR4-tropic (X4, syncytium-inducing) viruses occurs later in the infection and is associated with rapid disease progression. Here, we propose that the tropism of X4 viruses for naive CD4+ T cells is disadvantageous in early infection owing to the low division rate of these cells. In healthy individuals, the division rate of memory cells is nearly ten times higher than that of naive cells and thus the memory-cell tropism of R5 viruses could account for their dominance early in infection. As the division rate of naive T cells increases with CD4+ depletion, X4 viruses come to dominate in late disease." @default.
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- W2029619889 date "2002-06-01" @default.
- W2029619889 modified "2023-09-24" @default.
- W2029619889 title "Cell turnover and cell tropism in HIV-1 infection" @default.
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- W2029619889 doi "https://doi.org/10.1016/s0966-842x(02)02370-3" @default.
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