FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029635038> ?p ?o ?g. }

• W2029635038 endingPage "800" @default.
• W2029635038 startingPage "759" @default.
• W2029635038 abstract "Background The standard duration of treatment for acute group A beta hemolytic streptococcus (GABHS) pharyngitis with oral penicillin is 10 days. Shorter duration antibiotics may have comparable efficacy. Objectives To summarize the evidence regarding the efficacy of two to six days of newer oral antibiotics (short duration) compared to 10 days of oral penicillin (standard duration) in treating children with acute GABHS pharyngitis. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2007, issue 4), which contains the Acute Respiratory Infections Group's Specialized Register; the Database of Abstracts of Reviews of Effects (DARE); MEDLINE (1966 to October 2007); OLDMEDLINE (1950 to December 1965); and EMBASE (January 1990 to November 2007). Selection criteria Randomized controlled trials (RCTs) comparing short duration oral antibiotics to standard duration oral penicillin in children aged 1 to 18 years with acute GABHS pharyngitis. Data collection and analysis Two review authors scanned the titles and abstracts of retrieved citations and applied the inclusion criteria. We retrieved included studies in full and extracted data. Two review authors independently assessed trial quality. Main results Twenty studies were included with 13,102 cases of acute GABHS pharyngitis. Compared to standard duration treatment, the short duration treatment had shorter periods of fever (mean difference (MD) -0.30 days, 95% CI -0.45 to -0.14) and throat soreness (MD -0.50 days, 95% CI -0.78 to -0.22); lower risk of early clinical treatment failure (OR 0.80, 95% CI 0.67 to 0.94); no significant difference in early bacteriological treatment failure (OR 1.08, 95% CI 0.97 to 1.20), or late clinical recurrence (OR 0.95, 95% CI 0.83 to 1.08). However, the overall risk of late bacteriological recurrence was worse in the short duration treatment (OR 1.31, 95% CI 1.16 to 1.48), although no significant differences were found when studies of low dose azithromycin (10mg/kg) were eliminated (OR 1.06, 95% CI 0.92 to 1.22). Three studies reported long duration complications with no statistically significant difference (OR 0.53, 95% CI 0.17 to 1.64). Authors' conclusions Three to six days of oral antibiotics had comparable efficacy compared to the standard duration 10 day oral penicillin in treating children with acute GABHS pharyngitis. In countries with low rates of rheumatic fever, it appears safe and efficacious to treat children with acute GABHS pharyngitis with short duration antibiotics. In areas where the prevalence of rheumatic heart disease is still high, our results must be interpreted with caution. Plain Language Summary The effect of short duration versus standard duration antibiotic therapy for streptococcal throat infection in children Streptococcal throat infection is very common. A 10-day course of penicillin is prescribed mainly to protect against the complication of acute rheumatic fever, which occurs approximately 20 days after streptococcal throat or scarlet fever, and causes damage to the heart valves. Cases of acute rheumatic fever have dropped dramatically in high-income countries, with an annual incidence amongst school-aged children of 0.5 cases per 100,000, compared to 100 to 200 cases per 100,000 in low-income countries. Newer antibiotics, taken for a shorter duration, may have a comparable effect to penicillin taken for 10 days. We summarized the evidence in the medical literature regarding the effect of two to six days of oral antibiotics (short duration) in treating children with streptococcal throat infection, compared with 10 days of oral penicillin (standard duration). We searched the literature from 1951 to November 2007. Twenty studies were included with a total of 13,102 cases of streptococcal throat infection. The most common antibiotic studied was azithromycin (n = 6). Compared to standard duration, the short duration treatment had a shorter period of fever (mean difference (MD) -0.30 days, 95% CI -0.45 to -0.14) and sore throat (MD -0.50, 95% CI -0.78 to -0.22), and lower risk of early clinical treatment failure (OR 0.80, 95% CI 0.67 to 0.94), but there was no significant difference in early bacteriological treatment failure (OR 1.08, 95% CI 0.97 to 1.20), or late clinical recurrence (OR 0.95, 95% CI 0.83 to 1.08). The overall risk of late bacteriological recurrence was worse in the short duration treatment (OR 1.31, 95% CI 1.16 to 1.48). However, no significant difference was found when eliminating studies of low-dose azithromycin (10 mg/kg) (OR 1.06, 95% CI 0.92 to 1.22). The short duration treatment resulted in better compliance (non-compliance OR 0.21, 95% CI 0.16 to 0.29), but more side effects (OR 1.85, 95% CI 1.55 to 2.21). All side effects were self-limiting: mostly mild to moderate diarrhea, vomiting, and abdominal pain. Three studies reported the rate of long duration complications with no statistically significant difference (OR 0.53, 95% CI 0.17 to 1.64). Three to six days of oral antibiotics for children with streptococcal (strep) throat infection is a safe treatment with a comparable effect to the standard duration of 10 days of penicillin. However, our results must be interpreted with caution in low-income countries where acute rheumatic fever is still a problem." @default.
• W2029635038 created "2016-06-24" @default.
• W2029635038 creator A5006697253 @default.
• W2029635038 creator A5014389180 @default.
• W2029635038 creator A5020680009 @default.
• W2029635038 creator A5030631051 @default.
• W2029635038 creator A5060994210 @default.
• W2029635038 creator A5074495980 @default.
• W2029635038 date "2011-03-01" @default.
• W2029635038 modified "2023-10-14" @default.
• W2029635038 title "Cochrane review: Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children" @default.
• W2029635038 cites W1559813423 @default.
• W2029635038 cites W1963943434 @default.
• W2029635038 cites W1966602629 @default.
• W2029635038 cites W1972498125 @default.
• W2029635038 cites W1986215651 @default.
• W2029635038 cites W1987490391 @default.
• W2029635038 cites W2008083188 @default.
• W2029635038 cites W2014335701 @default.
• W2029635038 cites W2015428917 @default.
• W2029635038 cites W2021750587 @default.
• W2029635038 cites W2028426209 @default.
• W2029635038 cites W2040233478 @default.
• W2029635038 cites W2043754984 @default.
• W2029635038 cites W2054730891 @default.
• W2029635038 cites W2057212716 @default.
• W2029635038 cites W2057806510 @default.
• W2029635038 cites W2058410626 @default.
• W2029635038 cites W2063104452 @default.
• W2029635038 cites W2075128309 @default.
• W2029635038 cites W2081742495 @default.
• W2029635038 cites W2083725441 @default.
• W2029635038 cites W2088381237 @default.
• W2029635038 cites W2092088723 @default.
• W2029635038 cites W2093338276 @default.
• W2029635038 cites W2112569223 @default.
• W2029635038 cites W2112722239 @default.
• W2029635038 cites W2133017406 @default.
• W2029635038 cites W2133068508 @default.
• W2029635038 cites W2137023996 @default.
• W2029635038 cites W2141268045 @default.
• W2029635038 cites W2171780167 @default.
• W2029635038 cites W35393674 @default.
• W2029635038 doi "https://doi.org/10.1002/ebch.723" @default.
• W2029635038 hasPublicationYear "2011" @default.
• W2029635038 type Work @default.
• W2029635038 sameAs 2029635038 @default.
• W2029635038 citedByCount "0" @default.
• W2029635038 crossrefType "journal-article" @default.
• W2029635038 hasAuthorship W2029635038A5006697253 @default.
• W2029635038 hasAuthorship W2029635038A5014389180 @default.
• W2029635038 hasAuthorship W2029635038A5020680009 @default.
• W2029635038 hasAuthorship W2029635038A5030631051 @default.
• W2029635038 hasAuthorship W2029635038A5060994210 @default.
• W2029635038 hasAuthorship W2029635038A5074495980 @default.
• W2029635038 hasConcept C126322002 @default.
• W2029635038 hasConcept C168563851 @default.
• W2029635038 hasConcept C174802600 @default.
• W2029635038 hasConcept C187212893 @default.
• W2029635038 hasConcept C2776478404 @default.
• W2029635038 hasConcept C2779279270 @default.
• W2029635038 hasConcept C2910715184 @default.
• W2029635038 hasConcept C501593827 @default.
• W2029635038 hasConcept C71924100 @default.
• W2029635038 hasConcept C86803240 @default.
• W2029635038 hasConcept C89423630 @default.
• W2029635038 hasConceptScore W2029635038C126322002 @default.
• W2029635038 hasConceptScore W2029635038C168563851 @default.
• W2029635038 hasConceptScore W2029635038C174802600 @default.
• W2029635038 hasConceptScore W2029635038C187212893 @default.
• W2029635038 hasConceptScore W2029635038C2776478404 @default.
• W2029635038 hasConceptScore W2029635038C2779279270 @default.
• W2029635038 hasConceptScore W2029635038C2910715184 @default.
• W2029635038 hasConceptScore W2029635038C501593827 @default.
• W2029635038 hasConceptScore W2029635038C71924100 @default.
• W2029635038 hasConceptScore W2029635038C86803240 @default.
• W2029635038 hasConceptScore W2029635038C89423630 @default.
• W2029635038 hasIssue "2" @default.
• W2029635038 hasLocation W20296350381 @default.
• W2029635038 hasOpenAccess W2029635038 @default.
• W2029635038 hasPrimaryLocation W20296350381 @default.
• W2029635038 hasRelatedWork W182099582 @default.
• W2029635038 hasRelatedWork W2093736784 @default.
• W2029635038 hasRelatedWork W2308462248 @default.
• W2029635038 hasRelatedWork W2995630569 @default.
• W2029635038 hasRelatedWork W4035254 @default.
• W2029635038 hasRelatedWork W4213181775 @default.
• W2029635038 hasRelatedWork W4283266705 @default.
• W2029635038 hasRelatedWork W4291981996 @default.
• W2029635038 hasRelatedWork W4310833331 @default.
• W2029635038 hasRelatedWork W75274097 @default.
• W2029635038 hasVolume "6" @default.
• W2029635038 isParatext "false" @default.
• W2029635038 isRetracted "false" @default.
• W2029635038 magId "2029635038" @default.
• W2029635038 workType "article" @default.