Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029641808> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2029641808 endingPage "463" @default.
- W2029641808 startingPage "453" @default.
- W2029641808 abstract "To further define the sarcolemmal effects of ethanol and acetaldehyde, their effects on Na pump function were studied in synchronously contracting monolayers of neonatal rat myocardial cells. The effects of ethanol (10 mg/dl to 1000 mg/dl: 2 X 10(-3) M-0.2 M) and acetaldehyde (10(-6) M to 10(-4) M) on total 42K influx, ouabain-sensitive 42K influx, Na pump density (from specific 3H-ouabain binding) and pump turnover rates were measured. Applied acutely ethanol had no effect on 42K influx but after 30 min of treatment 42K influx was decreased by 13%, 23% and 48% in 100 mg/dl, 300 mg/dl and 1000 mg/dl ethanol respectively. This primarily reflected a decrease in mean ouabain-sensitive K+ influx from a control of 12.54 to 9.90, 8.95 and 6.68 (p-mol/cm2/s) in 100, 300 and 1000 mg/dl (2 X 10(-2) M, 6 X 10(-2) M) ethanol. Acetaldehyde in the concentrations tested had no effect on K+ influx. Ethanol treatment produced a decrease in Na pump density, maximum within 30 min and dose-dependent, at concentrations of 100 mg/dl (22%), 300 mg/dl (37%) and 1000 mg/dl (55%). Acetaldehyde had no effect on Na pump density. In the presence of ethanol (300 mg/dl and 1000 mg/dl) intracellular Na+ increased significantly and the Na+ efflux declined in parallel with the K+ influx. From the ouabain-sensitive K+ and Na+ fluxes and the Na pump density individual pump turnover rates were calculated at 62.5/s in control cells and 66/s and 84/s in cells treated with 300 mg/dl (6 X 10(-2) M) and 1000 mg/dl (0.2 M) respectively. We conclude that ethanol, but not acetaldehyde has a depressant effect on sarcolemmal Na pump function. The results suggest this is due primarily to a decrease in the number of sarcolemmal Na pump sites." @default.
- W2029641808 created "2016-06-24" @default.
- W2029641808 creator A5017580019 @default.
- W2029641808 creator A5062789732 @default.
- W2029641808 date "1987-05-01" @default.
- W2029641808 modified "2023-09-23" @default.
- W2029641808 title "The effect of ethanol and acetaldehyde on Na pump function in cultured rat heart cells1" @default.
- W2029641808 cites W127128872 @default.
- W2029641808 cites W1577871794 @default.
- W2029641808 cites W1967409321 @default.
- W2029641808 cites W1981058708 @default.
- W2029641808 cites W1982959314 @default.
- W2029641808 cites W1994408334 @default.
- W2029641808 cites W1996651364 @default.
- W2029641808 cites W2001717611 @default.
- W2029641808 cites W2003207800 @default.
- W2029641808 cites W2014655613 @default.
- W2029641808 cites W2020257945 @default.
- W2029641808 cites W2035932186 @default.
- W2029641808 cites W2038529937 @default.
- W2029641808 cites W2044060736 @default.
- W2029641808 cites W2051153339 @default.
- W2029641808 cites W2056599921 @default.
- W2029641808 cites W2057156999 @default.
- W2029641808 cites W2059271194 @default.
- W2029641808 cites W2073599382 @default.
- W2029641808 cites W2081962705 @default.
- W2029641808 cites W2082138067 @default.
- W2029641808 cites W2088641152 @default.
- W2029641808 cites W2090904275 @default.
- W2029641808 cites W2108664099 @default.
- W2029641808 cites W2135784387 @default.
- W2029641808 cites W2162293702 @default.
- W2029641808 cites W2242841094 @default.
- W2029641808 cites W2319463186 @default.
- W2029641808 cites W2343452461 @default.
- W2029641808 cites W2404426883 @default.
- W2029641808 cites W2417983195 @default.
- W2029641808 cites W2418193412 @default.
- W2029641808 cites W2434182073 @default.
- W2029641808 cites W2502894413 @default.
- W2029641808 cites W2523831432 @default.
- W2029641808 cites W577126974 @default.
- W2029641808 doi "https://doi.org/10.1016/s0022-2828(87)80397-8" @default.
- W2029641808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2442397" @default.
- W2029641808 hasPublicationYear "1987" @default.
- W2029641808 type Work @default.
- W2029641808 sameAs 2029641808 @default.
- W2029641808 citedByCount "20" @default.
- W2029641808 crossrefType "journal-article" @default.
- W2029641808 hasAuthorship W2029641808A5017580019 @default.
- W2029641808 hasAuthorship W2029641808A5062789732 @default.
- W2029641808 hasConcept C113196181 @default.
- W2029641808 hasConcept C13965031 @default.
- W2029641808 hasConcept C178790620 @default.
- W2029641808 hasConcept C185592680 @default.
- W2029641808 hasConcept C2777595113 @default.
- W2029641808 hasConcept C2779133857 @default.
- W2029641808 hasConcept C2780161600 @default.
- W2029641808 hasConcept C43617362 @default.
- W2029641808 hasConcept C537181965 @default.
- W2029641808 hasConcept C55493867 @default.
- W2029641808 hasConceptScore W2029641808C113196181 @default.
- W2029641808 hasConceptScore W2029641808C13965031 @default.
- W2029641808 hasConceptScore W2029641808C178790620 @default.
- W2029641808 hasConceptScore W2029641808C185592680 @default.
- W2029641808 hasConceptScore W2029641808C2777595113 @default.
- W2029641808 hasConceptScore W2029641808C2779133857 @default.
- W2029641808 hasConceptScore W2029641808C2780161600 @default.
- W2029641808 hasConceptScore W2029641808C43617362 @default.
- W2029641808 hasConceptScore W2029641808C537181965 @default.
- W2029641808 hasConceptScore W2029641808C55493867 @default.
- W2029641808 hasIssue "5" @default.
- W2029641808 hasLocation W20296418081 @default.
- W2029641808 hasLocation W20296418082 @default.
- W2029641808 hasOpenAccess W2029641808 @default.
- W2029641808 hasPrimaryLocation W20296418081 @default.
- W2029641808 hasRelatedWork W194561171 @default.
- W2029641808 hasRelatedWork W1967409321 @default.
- W2029641808 hasRelatedWork W1988816431 @default.
- W2029641808 hasRelatedWork W2029641808 @default.
- W2029641808 hasRelatedWork W2057885134 @default.
- W2029641808 hasRelatedWork W2291341487 @default.
- W2029641808 hasRelatedWork W2362755027 @default.
- W2029641808 hasRelatedWork W2366418472 @default.
- W2029641808 hasRelatedWork W2414549458 @default.
- W2029641808 hasRelatedWork W4586748 @default.
- W2029641808 hasVolume "19" @default.
- W2029641808 isParatext "false" @default.
- W2029641808 isRetracted "false" @default.
- W2029641808 magId "2029641808" @default.
- W2029641808 workType "article" @default.