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- W2029644583 endingPage "e111535" @default.
- W2029644583 startingPage "e111535" @default.
- W2029644583 abstract "The zinc transporter ZIP12, which is encoded by the gene slc39a12, has previously been shown to be important for neuronal differentiation in mouse Neuro-2a neuroblastoma cells and primary mouse neurons and necessary for neurulation during Xenopus tropicalis embryogenesis. However, relatively little is known about the biochemical properties, cellular regulation, or the physiological role of this gene. The hypothesis that ZIP12 is a zinc transporter important for nervous system function and development guided a comparative genetics approach to uncover the presence of ZIP12 in various genomes and identify conserved sequences and expression patterns associated with ZIP12. Ortholog detection of slc39a12 was conducted with reciprocal BLAST hits with the amino acid sequence of human ZIP12 in comparison to the human paralog ZIP4 and conserved local synteny between genomes. ZIP12 is present in the genomes of almost all vertebrates examined, from humans and other mammals to most teleost fish. However, ZIP12 appears to be absent from the zebrafish genome. The discrimination of ZIP12 compared to ZIP4 was unsuccessful or inconclusive in other invertebrate chordates and deuterostomes. Splice variation, due to the inclusion or exclusion of a conserved exon, is present in humans, rats, and cows and likely has biological significance. ZIP12 also possesses many putative di-leucine and tyrosine motifs often associated with intracellular trafficking, which may control cellular zinc uptake activity through the localization of ZIP12 within the cell. These findings highlight multiple aspects of ZIP12 at the biochemical, cellular, and physiological levels with likely biological significance. ZIP12 appears to have conserved function as a zinc uptake transporter in vertebrate nervous system development. Consequently, the role of ZIP12 may be an important link to reported congenital malformations in numerous animal models and humans that are caused by zinc deficiency." @default.
- W2029644583 created "2016-06-24" @default.
- W2029644583 creator A5062926912 @default.
- W2029644583 date "2014-11-06" @default.
- W2029644583 modified "2023-09-24" @default.
- W2029644583 title "Comparative Genomic Analysis of slc39a12/ZIP12: Insight into a Zinc Transporter Required for Vertebrate Nervous System Development" @default.
- W2029644583 cites W1521650410 @default.
- W2029644583 cites W1546288213 @default.
- W2029644583 cites W1568700266 @default.
- W2029644583 cites W1594381616 @default.
- W2029644583 cites W1963580691 @default.
- W2029644583 cites W1963581046 @default.
- W2029644583 cites W1964376836 @default.
- W2029644583 cites W1968830099 @default.
- W2029644583 cites W1970519717 @default.
- W2029644583 cites W1972120846 @default.
- W2029644583 cites W1978476503 @default.
- W2029644583 cites W1978647834 @default.
- W2029644583 cites W1981239255 @default.
- W2029644583 cites W1981794544 @default.
- W2029644583 cites W1984195830 @default.
- W2029644583 cites W1993487019 @default.
- W2029644583 cites W2002306043 @default.
- W2029644583 cites W2004666307 @default.
- W2029644583 cites W2004798786 @default.
- W2029644583 cites W2009329319 @default.
- W2029644583 cites W2017725062 @default.
- W2029644583 cites W2018642348 @default.
- W2029644583 cites W2024663868 @default.
- W2029644583 cites W2027762334 @default.
- W2029644583 cites W2032713755 @default.
- W2029644583 cites W2035594105 @default.
- W2029644583 cites W2041063545 @default.
- W2029644583 cites W2045497152 @default.
- W2029644583 cites W2050015430 @default.
- W2029644583 cites W2058103605 @default.
- W2029644583 cites W2059224185 @default.
- W2029644583 cites W2059682917 @default.
- W2029644583 cites W2060197301 @default.
- W2029644583 cites W2066097401 @default.
- W2029644583 cites W2067555693 @default.
- W2029644583 cites W2069063970 @default.
- W2029644583 cites W2070049608 @default.
- W2029644583 cites W2070228490 @default.
- W2029644583 cites W2070584671 @default.
- W2029644583 cites W2071989786 @default.
- W2029644583 cites W2079626874 @default.
- W2029644583 cites W2079822327 @default.
- W2029644583 cites W2080155677 @default.
- W2029644583 cites W2086011923 @default.
- W2029644583 cites W2087276505 @default.
- W2029644583 cites W2093460132 @default.
- W2029644583 cites W2094201044 @default.
- W2029644583 cites W2094713937 @default.
- W2029644583 cites W2095208806 @default.
- W2029644583 cites W2096525273 @default.
- W2029644583 cites W2097382368 @default.
- W2029644583 cites W2098715150 @default.
- W2029644583 cites W2099326239 @default.
- W2029644583 cites W2100321111 @default.
- W2029644583 cites W2101347991 @default.
- W2029644583 cites W2105350633 @default.
- W2029644583 cites W2107934935 @default.
- W2029644583 cites W2113904019 @default.
- W2029644583 cites W2115031948 @default.
- W2029644583 cites W2116790427 @default.
- W2029644583 cites W2120960764 @default.
- W2029644583 cites W2121496304 @default.
- W2029644583 cites W2125029076 @default.
- W2029644583 cites W2127367210 @default.
- W2029644583 cites W2127779357 @default.
- W2029644583 cites W2131071295 @default.
- W2029644583 cites W2135030836 @default.
- W2029644583 cites W2137322257 @default.
- W2029644583 cites W2138013352 @default.
- W2029644583 cites W2143593035 @default.
- W2029644583 cites W2148351021 @default.
- W2029644583 cites W2148820240 @default.
- W2029644583 cites W2149152197 @default.
- W2029644583 cites W2152819244 @default.
- W2029644583 cites W2158152050 @default.
- W2029644583 cites W2158283566 @default.
- W2029644583 cites W2158799272 @default.
- W2029644583 cites W2162184782 @default.
- W2029644583 cites W2162210817 @default.
- W2029644583 cites W2163580244 @default.
- W2029644583 cites W2163647339 @default.
- W2029644583 cites W2168338648 @default.
- W2029644583 cites W2169708399 @default.
- W2029644583 cites W2279310230 @default.
- W2029644583 cites W2280116323 @default.
- W2029644583 cites W2394877221 @default.
- W2029644583 cites W2395399671 @default.
- W2029644583 cites W2419258161 @default.
- W2029644583 cites W2916083703 @default.
- W2029644583 cites W4210290733 @default.
- W2029644583 cites W4231170962 @default.
- W2029644583 doi "https://doi.org/10.1371/journal.pone.0111535" @default.