FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029646788> ?p ?o ?g. }

• W2029646788 endingPage "89" @default.
• W2029646788 startingPage "83" @default.
• W2029646788 abstract "The in vitro contrast efficacy of liposome encapsulated gadolinium-[10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid] (GdHPDO3A) has been assessed by relaxometry. The internal concentrations were 150 and 250 mM Gd. Two types of liposome compositions were investigated: a phospholipid blend consisting of both hydrogenated phosphatidylcholine (HPC) and phosphatidylserine (HPS) with a gel-to-liquid crystalline phase transition temperature (Tm) of 50°C, and a mixture of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG) with a Tm of 41°C. The investigated liposome size range was 70–400 nm. The T1 and T2 relaxivities (r1 and r2) of liposome encapsulated GdHPDO3A were significantly reduced at 37°C and 0.47 T, compared to those of non-liposomal metal chelate, due to an exchange limitation of the dipolar relaxation process. The highest relaxivity values were obtained for the DPPC/DPPG liposomes, and were attributed to a higher liposome water permeability and to a more efficient water exchange across the membrane. A reduction in liposome size increased the r1, confirming the exchange limited dipolar relaxation. The increased r1 with increasing temperature demonstrated the prerequisite of rapid water exchange between the interior and exterior of the liposome for efficient dipolar relaxation enhancement. Susceptibility effects were present in the liposome systems as the r2/r1 ratio increased with increasing liposome size and internal Gd concentration. In summary, the current work has shown the influence of key physicochemical properties, such as liposome size, membrane composition and permeability, on the in vitro relaxivity of liposome encapsulated GdHPDO3A." @default.
• W2029646788 created "2016-06-24" @default.
• W2029646788 creator A5008989094 @default.
• W2029646788 creator A5017306707 @default.
• W2029646788 creator A5019515200 @default.
• W2029646788 creator A5090629590 @default.
• W2029646788 date "1999-02-01" @default.
• W2029646788 modified "2023-10-09" @default.
• W2029646788 title "Paramagnetic liposomes as MRI contrast agents: influence of liposomal physicochemical properties on the in vitro relaxivity" @default.
• W2029646788 cites W1973390997 @default.
• W2029646788 cites W1992105143 @default.
• W2029646788 cites W1994263735 @default.
• W2029646788 cites W2008444856 @default.
• W2029646788 cites W2011809144 @default.
• W2029646788 cites W2016977004 @default.
• W2029646788 cites W2027248540 @default.
• W2029646788 cites W2030345002 @default.
• W2029646788 cites W2034228245 @default.
• W2029646788 cites W2041828531 @default.
• W2029646788 cites W2044099442 @default.
• W2029646788 cites W2058007123 @default.
• W2029646788 cites W2066997037 @default.
• W2029646788 cites W2086809285 @default.
• W2029646788 cites W2121574589 @default.
• W2029646788 cites W2126662679 @default.
• W2029646788 cites W2137323616 @default.
• W2029646788 cites W2168332923 @default.
• W2029646788 cites W4205773964 @default.
• W2029646788 doi "https://doi.org/10.1016/s0730-725x(98)00141-6" @default.
• W2029646788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9888401" @default.
• W2029646788 hasPublicationYear "1999" @default.
• W2029646788 type Work @default.
• W2029646788 sameAs 2029646788 @default.
• W2029646788 citedByCount "137" @default.
• W2029646788 countsByYear W20296467882012 @default.
• W2029646788 countsByYear W20296467882013 @default.
• W2029646788 countsByYear W20296467882014 @default.
• W2029646788 countsByYear W20296467882015 @default.
• W2029646788 countsByYear W20296467882016 @default.
• W2029646788 countsByYear W20296467882017 @default.
• W2029646788 countsByYear W20296467882018 @default.
• W2029646788 countsByYear W20296467882019 @default.
• W2029646788 countsByYear W20296467882020 @default.
• W2029646788 countsByYear W20296467882021 @default.
• W2029646788 countsByYear W20296467882022 @default.
• W2029646788 countsByYear W20296467882023 @default.
• W2029646788 crossrefType "journal-article" @default.
• W2029646788 hasAuthorship W2029646788A5008989094 @default.
• W2029646788 hasAuthorship W2029646788A5017306707 @default.
• W2029646788 hasAuthorship W2029646788A5019515200 @default.
• W2029646788 hasAuthorship W2029646788A5090629590 @default.
• W2029646788 hasConcept C121332964 @default.
• W2029646788 hasConcept C12554922 @default.
• W2029646788 hasConcept C126838900 @default.
• W2029646788 hasConcept C143409427 @default.
• W2029646788 hasConcept C178790620 @default.
• W2029646788 hasConcept C185154212 @default.
• W2029646788 hasConcept C185592680 @default.
• W2029646788 hasConcept C2776330855 @default.
• W2029646788 hasConcept C2778918659 @default.
• W2029646788 hasConcept C2781172473 @default.
• W2029646788 hasConcept C41625074 @default.
• W2029646788 hasConcept C43617362 @default.
• W2029646788 hasConcept C46141821 @default.
• W2029646788 hasConcept C55493867 @default.
• W2029646788 hasConcept C557651011 @default.
• W2029646788 hasConcept C71924100 @default.
• W2029646788 hasConcept C73286259 @default.
• W2029646788 hasConcept C83042744 @default.
• W2029646788 hasConcept C86803240 @default.
• W2029646788 hasConceptScore W2029646788C121332964 @default.
• W2029646788 hasConceptScore W2029646788C12554922 @default.
• W2029646788 hasConceptScore W2029646788C126838900 @default.
• W2029646788 hasConceptScore W2029646788C143409427 @default.
• W2029646788 hasConceptScore W2029646788C178790620 @default.
• W2029646788 hasConceptScore W2029646788C185154212 @default.
• W2029646788 hasConceptScore W2029646788C185592680 @default.
• W2029646788 hasConceptScore W2029646788C2776330855 @default.
• W2029646788 hasConceptScore W2029646788C2778918659 @default.
• W2029646788 hasConceptScore W2029646788C2781172473 @default.
• W2029646788 hasConceptScore W2029646788C41625074 @default.
• W2029646788 hasConceptScore W2029646788C43617362 @default.
• W2029646788 hasConceptScore W2029646788C46141821 @default.
• W2029646788 hasConceptScore W2029646788C55493867 @default.
• W2029646788 hasConceptScore W2029646788C557651011 @default.
• W2029646788 hasConceptScore W2029646788C71924100 @default.
• W2029646788 hasConceptScore W2029646788C73286259 @default.
• W2029646788 hasConceptScore W2029646788C83042744 @default.
• W2029646788 hasConceptScore W2029646788C86803240 @default.
• W2029646788 hasIssue "1" @default.
• W2029646788 hasLocation W20296467881 @default.
• W2029646788 hasLocation W20296467882 @default.
• W2029646788 hasOpenAccess W2029646788 @default.
• W2029646788 hasPrimaryLocation W20296467881 @default.
• W2029646788 hasRelatedWork W1999694123 @default.
• W2029646788 hasRelatedWork W2037929872 @default.
• W2029646788 hasRelatedWork W2047591785 @default.
• W2029646788 hasRelatedWork W2060834095 @default.

• next