Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029648032> ?p ?o ?g. }
- W2029648032 endingPage "e1066" @default.
- W2029648032 startingPage "e1066" @default.
- W2029648032 abstract "Cells treated with hsp90 inhibitors exhibit pleiotropic changes, including an expansion of the mitochondrial compartment, accompanied by mitochondrial fragmentation and condensed mitochondrial morphology, with ultimate compromise of mitochondrial integrity and apoptosis.We identified several mitochondrial oxidative phosphorylation complex subunits, including several encoded by mtDNA, that are upregulated by hsp90 inhibitors, without corresponding changes in mRNA abundance. Post-transcriptional accumulation of mitochondrial proteins observed with hsp90 inhibitors is also seen in cells treated with proteasome inhibitors. Detailed studies of the OSCP subunit of mitochondrial F1F0-ATPase revealed the presence of mono- and polyubiquitinated OSCP in mitochondrial fractions. We demonstrate that processed OSCP undergoes retrotranslocation to a trypsin-sensitive form associated with the outer mitochondrial membrane. Inhibition of proteasome or hsp90 function results in accumulation of both correctly targeted and retrotranslocated mitochondrial OSCP.Cytosolic turnover of mitochondrial proteins demonstrates a novel connection between mitochondrial and cytosolic compartments through the ubiquitin-proteasome system. Analogous to defective protein folding in the endoplasmic reticulum, a mitochondrial unfolded protein response may play a role in the apoptotic effects of hsp90 and proteasome inhibitors." @default.
- W2029648032 created "2016-06-24" @default.
- W2029648032 creator A5002329262 @default.
- W2029648032 creator A5016626619 @default.
- W2029648032 creator A5082557039 @default.
- W2029648032 creator A5082913163 @default.
- W2029648032 date "2007-10-24" @default.
- W2029648032 modified "2023-10-09" @default.
- W2029648032 title "Hsp90 Inhibition Decreases Mitochondrial Protein Turnover" @default.
- W2029648032 cites W1558470115 @default.
- W2029648032 cites W1605149529 @default.
- W2029648032 cites W1830803900 @default.
- W2029648032 cites W1915442041 @default.
- W2029648032 cites W1971190195 @default.
- W2029648032 cites W1971725426 @default.
- W2029648032 cites W1983611855 @default.
- W2029648032 cites W1985235876 @default.
- W2029648032 cites W1988353980 @default.
- W2029648032 cites W1989512056 @default.
- W2029648032 cites W1990018583 @default.
- W2029648032 cites W1997294171 @default.
- W2029648032 cites W2001546169 @default.
- W2029648032 cites W2007422965 @default.
- W2029648032 cites W2007436833 @default.
- W2029648032 cites W2014656971 @default.
- W2029648032 cites W2023404148 @default.
- W2029648032 cites W2044810318 @default.
- W2029648032 cites W2051378993 @default.
- W2029648032 cites W2055538245 @default.
- W2029648032 cites W2065551750 @default.
- W2029648032 cites W2068169474 @default.
- W2029648032 cites W2070186209 @default.
- W2029648032 cites W2073454559 @default.
- W2029648032 cites W2080553628 @default.
- W2029648032 cites W2082390299 @default.
- W2029648032 cites W2084390827 @default.
- W2029648032 cites W2091403241 @default.
- W2029648032 cites W2110831274 @default.
- W2029648032 cites W2114425735 @default.
- W2029648032 cites W2132702191 @default.
- W2029648032 cites W2141018705 @default.
- W2029648032 cites W2143544675 @default.
- W2029648032 cites W2144708548 @default.
- W2029648032 cites W2152771182 @default.
- W2029648032 cites W2158049208 @default.
- W2029648032 cites W2167060626 @default.
- W2029648032 cites W2175029576 @default.
- W2029648032 cites W26424767 @default.
- W2029648032 doi "https://doi.org/10.1371/journal.pone.0001066" @default.
- W2029648032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2031825" @default.
- W2029648032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17957250" @default.
- W2029648032 hasPublicationYear "2007" @default.
- W2029648032 type Work @default.
- W2029648032 sameAs 2029648032 @default.
- W2029648032 citedByCount "132" @default.
- W2029648032 countsByYear W20296480322012 @default.
- W2029648032 countsByYear W20296480322013 @default.
- W2029648032 countsByYear W20296480322014 @default.
- W2029648032 countsByYear W20296480322015 @default.
- W2029648032 countsByYear W20296480322016 @default.
- W2029648032 countsByYear W20296480322017 @default.
- W2029648032 countsByYear W20296480322018 @default.
- W2029648032 countsByYear W20296480322019 @default.
- W2029648032 countsByYear W20296480322020 @default.
- W2029648032 countsByYear W20296480322021 @default.
- W2029648032 countsByYear W20296480322022 @default.
- W2029648032 countsByYear W20296480322023 @default.
- W2029648032 crossrefType "journal-article" @default.
- W2029648032 hasAuthorship W2029648032A5002329262 @default.
- W2029648032 hasAuthorship W2029648032A5016626619 @default.
- W2029648032 hasAuthorship W2029648032A5082557039 @default.
- W2029648032 hasAuthorship W2029648032A5082913163 @default.
- W2029648032 hasBestOaLocation W20296480321 @default.
- W2029648032 hasConcept C104292427 @default.
- W2029648032 hasConcept C104317684 @default.
- W2029648032 hasConcept C111491248 @default.
- W2029648032 hasConcept C158617107 @default.
- W2029648032 hasConcept C163950672 @default.
- W2029648032 hasConcept C173358068 @default.
- W2029648032 hasConcept C181199279 @default.
- W2029648032 hasConcept C18903297 @default.
- W2029648032 hasConcept C191015642 @default.
- W2029648032 hasConcept C205260736 @default.
- W2029648032 hasConcept C24586158 @default.
- W2029648032 hasConcept C27740335 @default.
- W2029648032 hasConcept C2775932338 @default.
- W2029648032 hasConcept C28859421 @default.
- W2029648032 hasConcept C55493867 @default.
- W2029648032 hasConcept C57600042 @default.
- W2029648032 hasConcept C75385678 @default.
- W2029648032 hasConcept C86803240 @default.
- W2029648032 hasConcept C95444343 @default.
- W2029648032 hasConcept C98539663 @default.
- W2029648032 hasConceptScore W2029648032C104292427 @default.
- W2029648032 hasConceptScore W2029648032C104317684 @default.
- W2029648032 hasConceptScore W2029648032C111491248 @default.
- W2029648032 hasConceptScore W2029648032C158617107 @default.
- W2029648032 hasConceptScore W2029648032C163950672 @default.