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• W2029653604 abstract "Primary gastrointestinal (GI) T-cell lymphoma is an infrequent and aggressive disease. However, rare indolent clonal T-cell proliferations in the GI tract have been described. We report 10 cases of GI involvement by an indolent T-cell lymphoproliferative disease, including 6 men and 4 women with a median age of 48 years (range, 15-77 years). Presenting symptoms included abdominal pain, diarrhea, vomiting, food intolerance, and dyspepsia. The lesions involved oral cavity, esophagus, stomach, small intestine, and colon. The infiltrates were dense, but nondestructive, and composed of small, mature-appearing lymphoid cells. Eight cases were CD4(-)/CD8(+), 1 was CD4(+)/CD8(-), and another was CD4(-)/CD8(-). T-cell receptor-γ chain gene rearrangement identified a clonal population in all 10 cases. There was no evidence of STAT3 SH2 domain mutation or activation. Six patients received chemotherapy because of an initial diagnosis of peripheral T-cell lymphoma, with little or no response, whereas the other 4 were followed without therapy. After a median follow-up of 38 months (range, 9-175 months), 9 patients were alive with persistent disease and 1 was free of disease. We propose the name indolent T-LPD of the GI tract for these lesions that can easily be mistaken for intestinal peripheral T-cell lymphoma, and lead to aggressive therapy." @default.
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• W2029653604 date "2013-11-21" @default.
• W2029653604 modified "2023-10-16" @default.
• W2029653604 title "Indolent T-cell lymphoproliferative disease of the gastrointestinal tract" @default.
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• W2029653604 doi "https://doi.org/10.1182/blood-2013-07-512830" @default.
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