FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029656502> ?p ?o ?g. }

• W2029656502 endingPage "295" @default.
• W2029656502 startingPage "287" @default.
• W2029656502 abstract "Immunization with a tetanus-protein (TT) pneumococcal polysaccharide (PPS) conjugate vaccine (Pnc1-TT) induces protective immunity against lethal pneumococcal infections in neonatal and infant mice, but anti-PPS IgG response and protective efficacy is lower than in adult mice. Here, we show that reduced antibody (Ab) response and protection against infections is directly related to impaired T cell response to the carrier. Whereas spleen cells from adult mice immunized with Pnc1-TT responded with proliferation and IFN-γ secretion to in vitro stimulation with TT, spleen cells from neonatal and infant mice did not. However, significant, but age dependent, Th2-cytokine responses were observed in mice immunized with Pnc1-TT. Impaired IFN-γ production upon TT-stimulation in vitro was also reflected in reduced IFN-γ/IL-5 ratio. The IL--5 response correlated with IgG anti-PPS titers, and the lack of PPS Ab in the majority of neonatal mice was clearly associated with absence of carrier-specific IL-5 production. These results show that immunization with Pnc1-TT induces carrier-specific T cell responses that increase with age and determine the levels of PPS-specific Ab elicited. Whereas a weak and Th2-biased response was observed in neonatal mice, infant mice showed a mixed Th1-Th2 response as observed in adults." @default.
• W2029656502 created "2016-06-24" @default.
• W2029656502 creator A5016700998 @default.
• W2029656502 creator A5030631117 @default.
• W2029656502 creator A5043520069 @default.
• W2029656502 creator A5049232805 @default.
• W2029656502 creator A5050777030 @default.
• W2029656502 creator A5054700717 @default.
• W2029656502 creator A5063678647 @default.
• W2029656502 date "2006-02-01" @default.
• W2029656502 modified "2023-10-12" @default.
• W2029656502 title "Early life T cell responses to pneumococcal conjugates increase with age and determine the polysaccharide-specific antibody response and protective efficacy" @default.
• W2029656502 cites W1487795229 @default.
• W2029656502 cites W1568684259 @default.
• W2029656502 cites W1578914995 @default.
• W2029656502 cites W1580627905 @default.
• W2029656502 cites W1597820912 @default.
• W2029656502 cites W1603097934 @default.
• W2029656502 cites W1630964770 @default.
• W2029656502 cites W1865652171 @default.
• W2029656502 cites W1906135384 @default.
• W2029656502 cites W1911500455 @default.
• W2029656502 cites W1964053262 @default.
• W2029656502 cites W1972941257 @default.
• W2029656502 cites W1978254568 @default.
• W2029656502 cites W1980593962 @default.
• W2029656502 cites W1984591972 @default.
• W2029656502 cites W1984997549 @default.
• W2029656502 cites W1988422289 @default.
• W2029656502 cites W1989073547 @default.
• W2029656502 cites W2005599815 @default.
• W2029656502 cites W2022936624 @default.
• W2029656502 cites W2023690749 @default.
• W2029656502 cites W2027451273 @default.
• W2029656502 cites W2044705783 @default.
• W2029656502 cites W2048172864 @default.
• W2029656502 cites W2056463452 @default.
• W2029656502 cites W2058541383 @default.
• W2029656502 cites W2059608310 @default.
• W2029656502 cites W2061123791 @default.
• W2029656502 cites W2061417796 @default.
• W2029656502 cites W2061598960 @default.
• W2029656502 cites W2066185722 @default.
• W2029656502 cites W2067923283 @default.
• W2029656502 cites W2070236526 @default.
• W2029656502 cites W2081651556 @default.
• W2029656502 cites W2085633099 @default.
• W2029656502 cites W2092095679 @default.
• W2029656502 cites W2096330203 @default.
• W2029656502 cites W2103584104 @default.
• W2029656502 cites W2108473659 @default.
• W2029656502 cites W2118314817 @default.
• W2029656502 cites W2125125294 @default.
• W2029656502 cites W2128783124 @default.
• W2029656502 cites W2129585763 @default.
• W2029656502 cites W2130532186 @default.
• W2029656502 cites W2144159905 @default.
• W2029656502 cites W2151674572 @default.
• W2029656502 cites W2161291046 @default.
• W2029656502 cites W2165618119 @default.
• W2029656502 cites W2170240282 @default.
• W2029656502 cites W2171838185 @default.
• W2029656502 cites W2177327503 @default.
• W2029656502 cites W2315972427 @default.
• W2029656502 cites W25250444 @default.
• W2029656502 cites W4255505159 @default.
• W2029656502 doi "https://doi.org/10.1002/eji.200535102" @default.
• W2029656502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16385627" @default.
• W2029656502 hasPublicationYear "2006" @default.
• W2029656502 type Work @default.
• W2029656502 sameAs 2029656502 @default.
• W2029656502 citedByCount "31" @default.
• W2029656502 countsByYear W20296565022012 @default.
• W2029656502 countsByYear W20296565022013 @default.
• W2029656502 countsByYear W20296565022014 @default.
• W2029656502 countsByYear W20296565022015 @default.
• W2029656502 countsByYear W20296565022016 @default.
• W2029656502 countsByYear W20296565022018 @default.
• W2029656502 countsByYear W20296565022019 @default.
• W2029656502 countsByYear W20296565022023 @default.
• W2029656502 crossrefType "journal-article" @default.
• W2029656502 hasAuthorship W2029656502A5016700998 @default.
• W2029656502 hasAuthorship W2029656502A5030631117 @default.
• W2029656502 hasAuthorship W2029656502A5043520069 @default.
• W2029656502 hasAuthorship W2029656502A5049232805 @default.
• W2029656502 hasAuthorship W2029656502A5050777030 @default.
• W2029656502 hasAuthorship W2029656502A5054700717 @default.
• W2029656502 hasAuthorship W2029656502A5063678647 @default.
• W2029656502 hasBestOaLocation W20296565021 @default.
• W2029656502 hasConcept C134018914 @default.
• W2029656502 hasConcept C159654299 @default.
• W2029656502 hasConcept C202751555 @default.
• W2029656502 hasConcept C203014093 @default.
• W2029656502 hasConcept C22070199 @default.
• W2029656502 hasConcept C24998067 @default.
• W2029656502 hasConcept C2776090121 @default.
• W2029656502 hasConcept C2778690821 @default.
• W2029656502 hasConcept C2779341262 @default.

• next