FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029657029> ?p ?o ?g. }

• W2029657029 endingPage "3058" @default.
• W2029657029 startingPage "3049" @default.
• W2029657029 abstract "The development of resistance to chemotherapeutic drugs is a major obstacle to the successful treatment of breast cancer. Ways to block or overcome this resistance are objects of intense research. We have previously shown that cancer cells selected for resistance against chemotherapeutic drugs or isolated from metastatic tumor sites have high levels of a calcium-dependent protein crosslinking enzyme, tissue transglutaminase (TG2) but no direct link between TG2 and resistance was established. As TG2 can associate with the β members of the integrin family of proteins, we hypothesized that TG2 promotes cell survival signaling pathways by activating integrins on the surface of these cells. To test this hypothesis, we studied the expression of TG2 and its interaction with various integrins in drug-resistant MCF-7 breast cancer cells. TG2 closely associated with β1 and β5 integrins on the surface of drug-resistant MCF-7 (MCF-7/Dox and MCF-7/RT) cells. The incubation of TG2-expressing drug-resistant MCF-7 cells on fibronectin (Fn)-coated surfaces strongly activated focal adhesion kinase, an event that leads to the activation of several downstream signaling pathways and, in turn, can confer apoptosis-resistant phenotype to cancer cells. The role of TG2 in Fn-mediated cell attachment, cell growth, and cell survival functions was further analysed by small interfering RNA (siRNA) approach. Inhibition of TG2 by siRNA-inhibited Fn-mediated cell attachment and cell survival functions in drug-resistant MCF-7 cells. We conclude that the expression of TG2 in breast cancer cells contributes to the development of the drug-resistance phenotype by promoting interaction between integrins and Fn." @default.
• W2029657029 created "2016-06-24" @default.
• W2029657029 creator A5042760638 @default.
• W2029657029 creator A5077873968 @default.
• W2029657029 creator A5089299130 @default.
• W2029657029 date "2006-01-30" @default.
• W2029657029 modified "2023-10-17" @default.
• W2029657029 title "Implications of increased tissue transglutaminase (TG2) expression in drug-resistant breast cancer (MCF-7) cells" @default.
• W2029657029 cites W132941827 @default.
• W2029657029 cites W1956645860 @default.
• W2029657029 cites W1964700296 @default.
• W2029657029 cites W1967455040 @default.
• W2029657029 cites W1975866732 @default.
• W2029657029 cites W1983778749 @default.
• W2029657029 cites W1984942174 @default.
• W2029657029 cites W1986366555 @default.
• W2029657029 cites W1988479585 @default.
• W2029657029 cites W1989780564 @default.
• W2029657029 cites W2004279850 @default.
• W2029657029 cites W2009501255 @default.
• W2029657029 cites W2014280822 @default.
• W2029657029 cites W2017386384 @default.
• W2029657029 cites W2022356764 @default.
• W2029657029 cites W2028691987 @default.
• W2029657029 cites W2036806537 @default.
• W2029657029 cites W2036908471 @default.
• W2029657029 cites W2063883710 @default.
• W2029657029 cites W2064024870 @default.
• W2029657029 cites W2064088942 @default.
• W2029657029 cites W2086314554 @default.
• W2029657029 cites W2100545793 @default.
• W2029657029 cites W2102690359 @default.
• W2029657029 cites W2103627235 @default.
• W2029657029 cites W2111414495 @default.
• W2029657029 cites W2117032654 @default.
• W2029657029 cites W2118052953 @default.
• W2029657029 cites W2131642772 @default.
• W2029657029 cites W2132031002 @default.
• W2029657029 cites W2135334875 @default.
• W2029657029 cites W2137064432 @default.
• W2029657029 cites W2144272048 @default.
• W2029657029 cites W2151257470 @default.
• W2029657029 cites W2164767056 @default.
• W2029657029 cites W2165525793 @default.
• W2029657029 cites W2326572877 @default.
• W2029657029 cites W4241333820 @default.
• W2029657029 cites W4312734170 @default.
• W2029657029 doi "https://doi.org/10.1038/sj.onc.1209324" @default.
• W2029657029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16449978" @default.
• W2029657029 hasPublicationYear "2006" @default.
• W2029657029 type Work @default.
• W2029657029 sameAs 2029657029 @default.
• W2029657029 citedByCount "125" @default.
• W2029657029 countsByYear W20296570292012 @default.
• W2029657029 countsByYear W20296570292013 @default.
• W2029657029 countsByYear W20296570292014 @default.
• W2029657029 countsByYear W20296570292015 @default.
• W2029657029 countsByYear W20296570292016 @default.
• W2029657029 countsByYear W20296570292017 @default.
• W2029657029 countsByYear W20296570292018 @default.
• W2029657029 countsByYear W20296570292019 @default.
• W2029657029 countsByYear W20296570292020 @default.
• W2029657029 countsByYear W20296570292021 @default.
• W2029657029 countsByYear W20296570292022 @default.
• W2029657029 countsByYear W20296570292023 @default.
• W2029657029 crossrefType "journal-article" @default.
• W2029657029 hasAuthorship W2029657029A5042760638 @default.
• W2029657029 hasAuthorship W2029657029A5077873968 @default.
• W2029657029 hasAuthorship W2029657029A5089299130 @default.
• W2029657029 hasBestOaLocation W20296570291 @default.
• W2029657029 hasConcept C109541995 @default.
• W2029657029 hasConcept C121608353 @default.
• W2029657029 hasConcept C1491633281 @default.
• W2029657029 hasConcept C178498320 @default.
• W2029657029 hasConcept C181199279 @default.
• W2029657029 hasConcept C195687474 @default.
• W2029657029 hasConcept C2775930923 @default.
• W2029657029 hasConcept C2994423619 @default.
• W2029657029 hasConcept C502942594 @default.
• W2029657029 hasConcept C530470458 @default.
• W2029657029 hasConcept C54355233 @default.
• W2029657029 hasConcept C55493867 @default.
• W2029657029 hasConcept C81885089 @default.
• W2029657029 hasConcept C85789140 @default.
• W2029657029 hasConcept C86492073 @default.
• W2029657029 hasConcept C86803240 @default.
• W2029657029 hasConcept C95444343 @default.
• W2029657029 hasConcept C96232424 @default.
• W2029657029 hasConceptScore W2029657029C109541995 @default.
• W2029657029 hasConceptScore W2029657029C121608353 @default.
• W2029657029 hasConceptScore W2029657029C1491633281 @default.
• W2029657029 hasConceptScore W2029657029C178498320 @default.
• W2029657029 hasConceptScore W2029657029C181199279 @default.
• W2029657029 hasConceptScore W2029657029C195687474 @default.
• W2029657029 hasConceptScore W2029657029C2775930923 @default.
• W2029657029 hasConceptScore W2029657029C2994423619 @default.
• W2029657029 hasConceptScore W2029657029C502942594 @default.
• W2029657029 hasConceptScore W2029657029C530470458 @default.

• next