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- W2029661945 abstract "Abstract A new technique was used to study the effects of purine antimetabolites on bone marrow colony forming cells (CFC), cells which are of critical importance in cancer chemotherapy. By extending the 3 H -thymidine suicide technique to include 3 H -purines, viz., hypoxanthine, deoxyadenosine, adenosine and adenine, the utilization of these purines for nucleic acid synthesis may be investigated. Antimetabolites may affect nucleic acid metabolism at several loci; to assess which of these loci were important to CFC, suicide studies were carried out with viable bone marrow cells. Primary cultures of mouse bone marrow were incubated alone and in the presence of 6 -mercaptopurine ( 6 -MP), with tritiated purines of sufficient radioactivity to inhibit colony formation (suicide). If any of the processes (e.g., transport, metabolism or incorporation of the 3 H -purines into nucleic acids) was inhibited, suicide by the 3 H -purines was prevented. Specific probes, viz., persantin, antimetabolites and nonradioactive purines, were used to localize pathways inhibited by 6 -MP. Nonradioactive purines were able to reverse the suicide of all tritiated purines. 6 -Mercaptopurine was able to reverse the suicide of 3 H -hypoxanthine but did not reverse the suicide of the other tritiated purines. We suggest that 6 -MP affects the metabolism of hypoxanthine in CFC, but not of adenine, adenosine or deoxyadenosine." @default.
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- W2029661945 date "1979-04-01" @default.
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- W2029661945 title "A suicide technique to study purine antimetabolites on bone marrow and tumor colony-forming cells" @default.
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- W2029661945 doi "https://doi.org/10.1016/0014-2964(79)90076-8" @default.
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