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- W2029672112 abstract "321 It has been suggested that hypercoaguability associated with ESRD may be attributable to diminished circulating levels of antithrombin III (ATIII). To assess whole blood clotting and rheological properties of blood, thromboelastography (TEG) and Sonoclot (SCT) analyses were performed on fresh specimens from 4 patient groups: control, maintenance hemodialysis, peritoneal dialysis and stable with well functioning kidney transplant recipients (txp). Recorded TEG indices included R (rate of thromboplastin generation), R + K (coagulation time), alpha angle (rate of clot formation), MA (clot strength) and % fibrinolysis (LY30, LY60) at 30 and 60 minutes. Sonoclot indices included onset (SonACT) and rate (Scr). ATIII levels were collected and assayed subsequently (Table)TableTEG and SCT parameters reflect quantitative and qualitative measures of both platelet and coagulation factor function. Patients with ESRD manifest thrombotic tendencies demonstrated by TEG, SCT and ATIII levels. Transplantation appears to significantly correct these values. Diminished levels of AT III levels were confirmed in both dialysis groups, and were not normalized in post-txp recipients. It remains to be determined whether the beneficial effect of txp can be attributed to platelet function or to other coagulation factors." @default.
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- W2029672112 date "1999-05-01" @default.
- W2029672112 modified "2023-09-24" @default.
- W2029672112 title "VISCOELASTIC MONITORS OF WHOLE BLOOD CLOT STRENGTH DEMONSTRATE THAT TRANSPLANTATION AMELIORATES THE HYPERCOAGUABILITY OF ENDSTAGE RENAL DISEASE (ESRD)" @default.
- W2029672112 doi "https://doi.org/10.1097/00007890-199905150-00345" @default.
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