FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029672419> ?p ?o ?g. }

• W2029672419 endingPage "194" @default.
• W2029672419 startingPage "187" @default.
• W2029672419 abstract "Hypotension and hypoperfusion during septic shock may contribute to tissue hypoxia and the intramyocardial inflammatory response that results in myocardial dysfunction. Therefore, we hypothesized that crystalloid or colloid resuscitation may alter myocardial dysfunction.Randomized, controlled, prospective animal study.University animal laboratory.Sprague-Dawley rats (250-300 g, n = 6/group).Rats received an intraperitoneal injection of 10 mg/kg lipopolysaccharide or control. One hour later, rats were randomized to intravenous resuscitation and received either 30 mL/kg normal saline, 10 mL/kg 10% pentastarch, 10 mL/kg 5% rat albumin, or no volume.We measured fractional shortening of cardiomyocytes isolated 5 hrs after lipopolysaccharide or control injection. In separate identical experiments, we measured myocardial interleukin-6, macrophage inhibitory protein-2, and nitric oxide synthase II protein and messenger RNA expression. Control fractional shortening of 24.1 +/- 2.2% was decreased by lipopolysaccharide to 18.8 +/- 1.2% (p <.001). Volume resuscitation after lipopolysaccharide significantly improved fractional shortening (p <.001). In particular, albumin resuscitation increased fractional shortening to 23.5 +/- 0.9%, which was more than either saline (fractional shortening 20.1 +/- 1.7%,p <.01) or pentastarch (fractional shortening 21.4 +/- 0.9%,p <.01). Myocardial macrophage inhibitory protein-2 protein and interleukin-6 and macrophage inhibitory protein-2 messenger RNA expression and neutrophil content were elevated following lipopolysaccharide (p <.05) but were not altered by volume resuscitation. Myocardial nitric oxide synthase II protein and messenger RNA expression increased following lipopolysaccharide (p <.01) and decreased with albumin resuscitation.We conclude that following lipopolysaccharide injection, volume resuscitation improves cardiomyocyte fractional shortening. Albumin resuscitation is particularly beneficial in preventing reduced cardiomyocyte contractility, and this benefit may be related to an albumin-induced reduction in nitric oxide synthase II protein and messenger RNA expression following endotoxin injection." @default.
• W2029672419 created "2016-06-24" @default.
• W2029672419 creator A5010687095 @default.
• W2029672419 creator A5024795435 @default.
• W2029672419 creator A5028713849 @default.
• W2029672419 creator A5031534292 @default.
• W2029672419 creator A5090576091 @default.
• W2029672419 date "2003-01-01" @default.
• W2029672419 modified "2023-10-14" @default.
• W2029672419 title "Albumin resuscitation increases cardiomyocyte contractility and decreases nitric oxide synthase II expression in rat endotoxemia*" @default.
• W2029672419 cites W139789830 @default.
• W2029672419 cites W1483781417 @default.
• W2029672419 cites W1967541128 @default.
• W2029672419 cites W1967705851 @default.
• W2029672419 cites W1981361599 @default.
• W2029672419 cites W1986947248 @default.
• W2029672419 cites W1990613018 @default.
• W2029672419 cites W1997093722 @default.
• W2029672419 cites W2005638659 @default.
• W2029672419 cites W2006919847 @default.
• W2029672419 cites W2008534021 @default.
• W2029672419 cites W2021939309 @default.
• W2029672419 cites W2023722505 @default.
• W2029672419 cites W2027215429 @default.
• W2029672419 cites W2034588904 @default.
• W2029672419 cites W2036909269 @default.
• W2029672419 cites W2058976893 @default.
• W2029672419 cites W2069642844 @default.
• W2029672419 cites W2069661887 @default.
• W2029672419 cites W2071132777 @default.
• W2029672419 cites W2087783787 @default.
• W2029672419 cites W2090092428 @default.
• W2029672419 cites W2098647819 @default.
• W2029672419 cites W2125387962 @default.
• W2029672419 cites W2130670511 @default.
• W2029672419 cites W2139347063 @default.
• W2029672419 cites W2143643664 @default.
• W2029672419 cites W2146566721 @default.
• W2029672419 cites W2147900884 @default.
• W2029672419 cites W2161089523 @default.
• W2029672419 cites W2231799708 @default.
• W2029672419 cites W2281457340 @default.
• W2029672419 cites W2288348491 @default.
• W2029672419 cites W2338143518 @default.
• W2029672419 cites W2463380215 @default.
• W2029672419 cites W81707709 @default.
• W2029672419 doi "https://doi.org/10.1097/00003246-200301000-00029" @default.
• W2029672419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12545014" @default.
• W2029672419 hasPublicationYear "2003" @default.
• W2029672419 type Work @default.
• W2029672419 sameAs 2029672419 @default.
• W2029672419 citedByCount "40" @default.
• W2029672419 countsByYear W20296724192012 @default.
• W2029672419 countsByYear W20296724192013 @default.
• W2029672419 countsByYear W20296724192014 @default.
• W2029672419 countsByYear W20296724192015 @default.
• W2029672419 countsByYear W20296724192016 @default.
• W2029672419 countsByYear W20296724192017 @default.
• W2029672419 countsByYear W20296724192020 @default.
• W2029672419 countsByYear W20296724192021 @default.
• W2029672419 countsByYear W20296724192023 @default.
• W2029672419 crossrefType "journal-article" @default.
• W2029672419 hasAuthorship W2029672419A5010687095 @default.
• W2029672419 hasAuthorship W2029672419A5024795435 @default.
• W2029672419 hasAuthorship W2029672419A5028713849 @default.
• W2029672419 hasAuthorship W2029672419A5031534292 @default.
• W2029672419 hasAuthorship W2029672419A5090576091 @default.
• W2029672419 hasConcept C126322002 @default.
• W2029672419 hasConcept C134018914 @default.
• W2029672419 hasConcept C2776125364 @default.
• W2029672419 hasConcept C2777397205 @default.
• W2029672419 hasConcept C2777622882 @default.
• W2029672419 hasConcept C2778165595 @default.
• W2029672419 hasConcept C2778384902 @default.
• W2029672419 hasConcept C2778754761 @default.
• W2029672419 hasConcept C39133596 @default.
• W2029672419 hasConcept C42219234 @default.
• W2029672419 hasConcept C519581460 @default.
• W2029672419 hasConcept C71924100 @default.
• W2029672419 hasConceptScore W2029672419C126322002 @default.
• W2029672419 hasConceptScore W2029672419C134018914 @default.
• W2029672419 hasConceptScore W2029672419C2776125364 @default.
• W2029672419 hasConceptScore W2029672419C2777397205 @default.
• W2029672419 hasConceptScore W2029672419C2777622882 @default.
• W2029672419 hasConceptScore W2029672419C2778165595 @default.
• W2029672419 hasConceptScore W2029672419C2778384902 @default.
• W2029672419 hasConceptScore W2029672419C2778754761 @default.
• W2029672419 hasConceptScore W2029672419C39133596 @default.
• W2029672419 hasConceptScore W2029672419C42219234 @default.
• W2029672419 hasConceptScore W2029672419C519581460 @default.
• W2029672419 hasConceptScore W2029672419C71924100 @default.
• W2029672419 hasIssue "1" @default.
• W2029672419 hasLocation W20296724191 @default.
• W2029672419 hasLocation W20296724192 @default.
• W2029672419 hasOpenAccess W2029672419 @default.
• W2029672419 hasPrimaryLocation W20296724191 @default.
• W2029672419 hasRelatedWork W1585358533 @default.
• W2029672419 hasRelatedWork W1968811274 @default.

• next