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- W2029673876 abstract "To compare the impact of various measures of adherence to antidepressant (AD) therapy on the estimation of the rate of depressive relapse using claims database. Using the Korean Health Insurance Review & Assessment Service (HIRA) claims database (2006-2008), patients aged 18-84 without medical visit due to depression (ICD 10=F06.3, F31.3, F31.4, F32, F33, F34.1, F38.1, F41.2) within 6 months before the first observed prescription of ADs between July 2006 to Jun 2007 (18 months index period), and with at least 3 psychiatric visits within 3 months from index date were identified. ADs were categorized as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and new antidepressants (NADs). The adherence measures of AD therapy include 90-days medication possession ratio (MPR, <75% as nonadherent), persistence (duration of uninterrupted therapy > 90 days with 14-day permissible gap), and switching of AD class within 180-days were used. Relapse was defined as hospitalization or emergency department visit due to depression, suicide attempts, or reinitiation of AD therapy after at least 6 months from previous AD treatment. Cox proportional hazards model was used to estimate risk ratios of relapse with 95% confidence intervals for each adherence measure. A total of 88,079 patients satisfied the selection criteria, among which mean age of 45.2 years and 67.3% of women. Overall relapse rate was 29.5%. Adherence (MPR≥75%) or persistence (duration of uninterrupted therapy >90 days) showed non-significant estimates of relapse risk (aRR=0.99[0.97-1.02] and 1.01[0.97-1.04], respectively). Patients who switched AD class within 180 days showed increased risk of relapse (aRR=1.18[1.15-1.21]). Various definitions of adherence led to different estimates of relapse rate. Diverse aspects of adherence should be considered when studying the association between the medication adherence and clinical outcomes." @default.
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- W2029673876 date "2011-05-01" @default.
- W2029673876 modified "2023-09-30" @default.
- W2029673876 title "PMH81 RELATIONSHIP BETWEEN ADHERENCE TO ANTIDEPRESSANT TREATMENTS AND DEPRESSIVE RELAPSE" @default.
- W2029673876 doi "https://doi.org/10.1016/j.jval.2011.02.1105" @default.
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