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• W2029673910 abstract "The insensitivity of the early TSH radioimmunoassays limited investigations of thyroid hormone action on pituitary TSH secretion to studies of hypothyroid rats and humans (1, 2). Now that more sensitive TSH immunometric assays are able to measure serum TSH concentrations in the subnormal range (3). it is possible to study thyroid hormone inhibition of pituitary TSH secretion in euthyroid human subjects. In the well­ designed study of Sydow et al. (4), groups of euthyroid male volunteers were given different oral doses of thyroxine (25-150 Itgq.i.d.) for 10 days, during which time the relationships between the thyroxine dose and the resultant suppression of serum TSH and thyroglo­ bulin (TG) concentrations were studied. The data showed that both serum TSH and Tg concentrations fell over time with single monoexpontential suppression patterns. Further, the rates of decline for both serum TSH and serum Tg were proportional to the thyroxine dose administered. It should be emphasized that this study was conducted under non-steady-state conditions whereby neither serum TSH nor TG concentrations reached their nadirs during the 10-day observation period. The Sydow study (4) emphasizes three important concepts concerning the negative feedback of thyroid hormones on pituitary TSH secretion. Firstly, some suppression of serum TSH was detected even at a low T ... dose (25 ftg) that did not produce a measurable change in serum free T4 (FT ... ) concentrations. The exquisite sensitivity of the pituitary to minor excur­ sions in the FT 4 concentration shows that the logj linear serum TSHjFT ... relationship found at a steady state (5) is also seen during periods of disequilibrium. Secondly, serum TSH suppression was seen without an elevation in the serum FT3I concentration. In fact, a detectable rise in the serum FT 31 was only seen on the 10th day following the administration of the largest T ... dose (150 ftg). This emphasizes the work of Larsen and others (6) showing that it is local T 3' generated from T 4 within the pituitary by the 5'­ deiodinase enzyme system(s), that mediates thyrox­ ine's negative feedback on pituitary TSH secretion. Thirdly, the failure of serum FT 31 concentrations to rise in parallel with the rise in FT4I is in accord with the concept that the 5' -deiodinase enzyme systems are autoregulated, such that a normal circulating T 3" @default.
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• W2029673910 date "1996-09-01" @default.
• W2029673910 modified "2023-09-27" @default.
• W2029673910 title "Dynamics of thyroid hormone suppression of serum thyrotropin: an invited commentary" @default.
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• W2029673910 doi "https://doi.org/10.1530/eje.0.1350285" @default.
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