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• W2029676141 startingPage "641" @default.
• W2029676141 abstract "The relationship between the effects of the N-methyl-D-aspartate (NMDA) antagonist MK-801 on acute responses to ethanol and its ability to block ethanol sensitization and tolerance was examined in DBA/2J mice. Cross-sensitization between these drugs was also studied. Repeated administration of 0.1 mg/kg MK-801 with ethanol potentiated, whereas 0.25 mg/kg attenuated, sensitization to ethanol's locomotor stimulant effects; rearing was similarly affected. There was evidence for cross-sensitization between ethanol and 0.25 mg/kg MK-801. MK-801 potentiated ethanol's ataxic effects in the grid test, but had no effect on tolerance to this effect. MK-801's effects on ethanol sensitization appeared to be related to its own behavioral effects, rather than NMDA receptor blockade per se. Further, these studies demonstrate dissociation between ethanol sensitization and tolerance." @default.
• W2029676141 created "2016-06-24" @default.
• W2029676141 creator A5008609077 @default.
• W2029676141 creator A5048853796 @default.
• W2029676141 date "2003-01-01" @default.
• W2029676141 modified "2023-09-23" @default.
• W2029676141 title "Bivalent effects of MK-801 on ethanol-induced sensitization do not parallel its effects on ethanol-induced tolerance." @default.
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• W2029676141 doi "https://doi.org/10.1037/0735-7044.117.3.641" @default.
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