Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029680003> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2029680003 endingPage "671" @default.
- W2029680003 startingPage "665" @default.
- W2029680003 abstract "Bioavailability data for herbal supplements in humans is not readily available or is difficult to obtain, because of the complexity of the composition and the diversity of the constituents. Potency of an herbal extract is due to the synergistic interactions between several constituents. Thus, the use of in silico methods is an attractive alternative to predict the qualitative intestinal permeability of the active constituents for the selection of appropriate bioavailability markers. Molecular descriptors such as CLogP, minimal cross-sectional area and polar surface area of 37 active components from selected herbal extracts such as milk thistle, kava, ginkgo, ginseng, valerian, black cohosh and garlic were estimated. In vitro permeability of the compounds was determined by SimBioDAS an in vitro epithelial cell permeability assay. Based on the in silico descriptors and their relationship with the in vitro permeability, the qualitative intestinal permeability of the active compounds was predicted. Bioavailability and bioequivalence markers were predicted for kava, Ginkgo biloba and milk thistle. Choosing a compound which has the least intestinal permeability as a marker is the most conservative approach toward ensuring the bioavailability of the entire extract." @default.
- W2029680003 created "2016-06-24" @default.
- W2029680003 creator A5045222772 @default.
- W2029680003 creator A5089505115 @default.
- W2029680003 date "2008-05-16" @default.
- W2029680003 modified "2023-09-27" @default.
- W2029680003 title "Selection of Bioavailability Markers for Herbal Extracts Based on <i>In Silico</i> Descriptors and Their Correlation to <i>In Vitro</i> Permeability" @default.
- W2029680003 cites W1596837460 @default.
- W2029680003 cites W1968105489 @default.
- W2029680003 cites W1981848002 @default.
- W2029680003 cites W1990057891 @default.
- W2029680003 cites W1998584026 @default.
- W2029680003 cites W2003641863 @default.
- W2029680003 cites W2023621385 @default.
- W2029680003 cites W2041801408 @default.
- W2029680003 cites W2067468321 @default.
- W2029680003 cites W2070125401 @default.
- W2029680003 cites W2085150721 @default.
- W2029680003 cites W2085426347 @default.
- W2029680003 cites W2144934601 @default.
- W2029680003 cites W2952696261 @default.
- W2029680003 cites W4248107770 @default.
- W2029680003 doi "https://doi.org/10.1021/mp700153h" @default.
- W2029680003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18481869" @default.
- W2029680003 hasPublicationYear "2008" @default.
- W2029680003 type Work @default.
- W2029680003 sameAs 2029680003 @default.
- W2029680003 citedByCount "8" @default.
- W2029680003 countsByYear W20296800032013 @default.
- W2029680003 countsByYear W20296800032014 @default.
- W2029680003 countsByYear W20296800032015 @default.
- W2029680003 countsByYear W20296800032020 @default.
- W2029680003 countsByYear W20296800032021 @default.
- W2029680003 crossrefType "journal-article" @default.
- W2029680003 hasAuthorship W2029680003A5045222772 @default.
- W2029680003 hasAuthorship W2029680003A5089505115 @default.
- W2029680003 hasConcept C104317684 @default.
- W2029680003 hasConcept C181389837 @default.
- W2029680003 hasConcept C185592680 @default.
- W2029680003 hasConcept C2775905019 @default.
- W2029680003 hasConcept C2778004101 @default.
- W2029680003 hasConcept C2779034068 @default.
- W2029680003 hasConcept C2909423643 @default.
- W2029680003 hasConcept C55493867 @default.
- W2029680003 hasConcept C556039675 @default.
- W2029680003 hasConcept C71924100 @default.
- W2029680003 hasConcept C86803240 @default.
- W2029680003 hasConcept C98274493 @default.
- W2029680003 hasConceptScore W2029680003C104317684 @default.
- W2029680003 hasConceptScore W2029680003C181389837 @default.
- W2029680003 hasConceptScore W2029680003C185592680 @default.
- W2029680003 hasConceptScore W2029680003C2775905019 @default.
- W2029680003 hasConceptScore W2029680003C2778004101 @default.
- W2029680003 hasConceptScore W2029680003C2779034068 @default.
- W2029680003 hasConceptScore W2029680003C2909423643 @default.
- W2029680003 hasConceptScore W2029680003C55493867 @default.
- W2029680003 hasConceptScore W2029680003C556039675 @default.
- W2029680003 hasConceptScore W2029680003C71924100 @default.
- W2029680003 hasConceptScore W2029680003C86803240 @default.
- W2029680003 hasConceptScore W2029680003C98274493 @default.
- W2029680003 hasIssue "4" @default.
- W2029680003 hasLocation W20296800031 @default.
- W2029680003 hasLocation W20296800032 @default.
- W2029680003 hasOpenAccess W2029680003 @default.
- W2029680003 hasPrimaryLocation W20296800031 @default.
- W2029680003 hasRelatedWork W1748908920 @default.
- W2029680003 hasRelatedWork W2029680003 @default.
- W2029680003 hasRelatedWork W2595931317 @default.
- W2029680003 hasRelatedWork W2884124979 @default.
- W2029680003 hasRelatedWork W2966093382 @default.
- W2029680003 hasRelatedWork W3092261301 @default.
- W2029680003 hasRelatedWork W3130416569 @default.
- W2029680003 hasRelatedWork W3137793385 @default.
- W2029680003 hasRelatedWork W3158819088 @default.
- W2029680003 hasRelatedWork W4285393154 @default.
- W2029680003 hasVolume "5" @default.
- W2029680003 isParatext "false" @default.
- W2029680003 isRetracted "false" @default.
- W2029680003 magId "2029680003" @default.
- W2029680003 workType "article" @default.