FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029681710> ?p ?o ?g. }

• W2029681710 endingPage "1476" @default.
• W2029681710 startingPage "1471" @default.
• W2029681710 abstract "Male cynomolgus monkeys (n = 10) were subjected to varying durations of global cerebral ischemia to determine the relation between dose (ischemic duration) and response (outcome). Each monkey was anesthetized with halothane, and global cerebral ischemia was produced by a neck tourniquet and trimethaphan-induced hypotension. The animal was subjected to 3 (n = 3), 9 (n = 3), or 12 (n = 4) minutes of ischemia. Neurological examinations were performed daily for 30 days or until the monkey was neurologically normal. Approximately 1 month after ischemia, the animal was evaluated for evidence of neurobehavioral abnormalities with the nonmatching to sample test. When testing was complete, the monkey was killed with an overdose of pentobarbital and the brain perfused with formalin and removed for histopathologic analysis, with particular attention devoted to the hippocampal CA1 region. Monkeys subjected to 3 or 9 minutes of ischemia were neurologically normal (except for a very mild injury in one 9-minute animal) immediately after ischemia and had normal CA1 histology. Monkeys subjected to 12 minutes of ischemia were grossly abnormal neurologically after ischemia, but two of the four animals made a complete recovery (neurological deficit score of 0) by 30 days. Monkeys subjected to 12 minutes of ischemia had mild damage in the CA1 region, with all other brain regions appearing normal. None of the animals had demonstrable decrements in neurobehavioral function as measured by the nonmatching to sample test. We conclude that neurobehavioral testing after global cerebral ischemia in primates is feasible, but the ischemic time necessary to produce CA1 damage that could potentially be quantified antemortem with the nonmatching to sample test is greater than 12 minutes in cynomolgus monkeys and may produce temporary severe gross neurological abnormalities as well." @default.
• W2029681710 created "2016-06-24" @default.
• W2029681710 creator A5009956588 @default.
• W2029681710 creator A5044042533 @default.
• W2029681710 creator A5069864757 @default.
• W2029681710 creator A5090074550 @default.
• W2029681710 date "1992-10-01" @default.
• W2029681710 modified "2023-09-25" @default.
• W2029681710 title "Effects of ischemia duration on neurological outcome, CA1 histopathology, and nonmatching to sample learning in monkeys." @default.
• W2029681710 cites W1598800837 @default.
• W2029681710 cites W1970863591 @default.
• W2029681710 cites W1983967413 @default.
• W2029681710 cites W2000540525 @default.
• W2029681710 cites W2008283809 @default.
• W2029681710 cites W2054078152 @default.
• W2029681710 cites W2057753858 @default.
• W2029681710 cites W2076315357 @default.
• W2029681710 cites W2100238929 @default.
• W2029681710 cites W2125481891 @default.
• W2029681710 cites W2133459825 @default.
• W2029681710 cites W3002740628 @default.
• W2029681710 cites W4232151349 @default.
• W2029681710 cites W4238114310 @default.
• W2029681710 cites W4238666786 @default.
• W2029681710 cites W4317926476 @default.
• W2029681710 doi "https://doi.org/10.1161/01.str.23.10.1471" @default.
• W2029681710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1412584" @default.
• W2029681710 hasPublicationYear "1992" @default.
• W2029681710 type Work @default.
• W2029681710 sameAs 2029681710 @default.
• W2029681710 citedByCount "16" @default.
• W2029681710 countsByYear W20296817102012 @default.
• W2029681710 countsByYear W20296817102014 @default.
• W2029681710 countsByYear W20296817102017 @default.
• W2029681710 crossrefType "journal-article" @default.
• W2029681710 hasAuthorship W2029681710A5009956588 @default.
• W2029681710 hasAuthorship W2029681710A5044042533 @default.
• W2029681710 hasAuthorship W2029681710A5069864757 @default.
• W2029681710 hasAuthorship W2029681710A5090074550 @default.
• W2029681710 hasBestOaLocation W20296817101 @default.
• W2029681710 hasConcept C126322002 @default.
• W2029681710 hasConcept C142724271 @default.
• W2029681710 hasConcept C148762608 @default.
• W2029681710 hasConcept C2776755955 @default.
• W2029681710 hasConcept C2776932660 @default.
• W2029681710 hasConcept C2778820722 @default.
• W2029681710 hasConcept C2779281540 @default.
• W2029681710 hasConcept C42219234 @default.
• W2029681710 hasConcept C541997718 @default.
• W2029681710 hasConcept C544855455 @default.
• W2029681710 hasConcept C71924100 @default.
• W2029681710 hasConceptScore W2029681710C126322002 @default.
• W2029681710 hasConceptScore W2029681710C142724271 @default.
• W2029681710 hasConceptScore W2029681710C148762608 @default.
• W2029681710 hasConceptScore W2029681710C2776755955 @default.
• W2029681710 hasConceptScore W2029681710C2776932660 @default.
• W2029681710 hasConceptScore W2029681710C2778820722 @default.
• W2029681710 hasConceptScore W2029681710C2779281540 @default.
• W2029681710 hasConceptScore W2029681710C42219234 @default.
• W2029681710 hasConceptScore W2029681710C541997718 @default.
• W2029681710 hasConceptScore W2029681710C544855455 @default.
• W2029681710 hasConceptScore W2029681710C71924100 @default.
• W2029681710 hasIssue "10" @default.
• W2029681710 hasLocation W20296817101 @default.
• W2029681710 hasLocation W20296817102 @default.
• W2029681710 hasLocation W20296817103 @default.
• W2029681710 hasOpenAccess W2029681710 @default.
• W2029681710 hasPrimaryLocation W20296817101 @default.
• W2029681710 hasRelatedWork W1496823793 @default.
• W2029681710 hasRelatedWork W1983232563 @default.
• W2029681710 hasRelatedWork W1987706450 @default.
• W2029681710 hasRelatedWork W2029681710 @default.
• W2029681710 hasRelatedWork W2050084962 @default.
• W2029681710 hasRelatedWork W2063566458 @default.
• W2029681710 hasRelatedWork W2088850912 @default.
• W2029681710 hasRelatedWork W2128889275 @default.
• W2029681710 hasRelatedWork W2375208941 @default.
• W2029681710 hasRelatedWork W3145467656 @default.
• W2029681710 hasVolume "23" @default.
• W2029681710 isParatext "false" @default.
• W2029681710 isRetracted "false" @default.
• W2029681710 magId "2029681710" @default.
• W2029681710 workType "article" @default.