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• W2029683108 abstract "THERE is ample evidence in the literature, collated and summarized by Roux (1954) and Bonnet (1954), that cortisone and ACTH are, generally speaking, effective in reducing the duration and intensity of the disease process in temporal arteritis. This has now been proved by serial biopsy (Harrison, Harrison, and Kopelman, 1955), though early reports were inconclusive in this respect. It has been suggested that this treatment also inhibits further extension of the lesions, implying that continued therapy is essential pending the natural termination of the process or alternatively of the life of its victim. Although the manifestations of this disease are protean and sometimes fatal, visual loss is by far the commonest of those causing disablement, occurring in as many as 44 per cent. of cases (Roux, 1954) and being frequently total in degree; 15 per cent. of patients are said by Bruce (1949) to become virtually blind, and 26 per cent. by Whitfield, Cook, Evans, and Rudd (1953). Bonnet (1954) concluded that 50 per cent. of cases have ocular complications, and that 25 per cent. lose all useful vision. We should therefore rate the efficacy of any line of treatment primarily on its value in combating and restoring visual loss. We must first, in any investigation into the effects of any drug on any disease, consider the behaviour of cases which have not had the benefit of such treatment. It is surprising to find that this simple precaution is frequently not observed in medical writings. On examining the relevant literature, we find that not all the cases annotated are, for various reasons, suitable for abstraction and analysis, but the following articles are worthy of mention. Parsons-Smith (1952) observed definite slight improvement in seven eyes, none in eleven eyes, and uncertain results in other eyes in cases of temporal arteritis showing visual loss. Kendall (1953) found slight improvement in only one eye out of ten affected. Bruce (1949) in his analysis noted only two cases with reasonable visual recovery out of 34. Meadows (1954) described twelve patients with varying degrees of blindness in both eyes; only one eye out of the 24 showed any recovery. Thus we may expect some degree of recovery in a percentage of cases varying from" @default.
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• W2029683108 date "1956-07-01" @default.
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• W2029683108 title "Cortisone Therapy of Visual Loss in Temporal Arteritis" @default.
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• W2029683108 doi "https://doi.org/10.1136/bjo.40.7.430" @default.
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