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• W2029685741 abstract "As a continuation of our research and with the aim of obtaining new antituberculosis agents which can improve the current chemotherapeutic antituberculosis treatments, new series of quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro antituberculosis activity against Mycobacterium tuberculosis strain H37Rv, using the radiometric BACTEC 460-TB methodology. Active compounds were also screened by serial dilution to assess toxicity to a VERO cell line. The results indicate that some compounds exhibited a good antituberculosis activity and the arylcarboxamide analogues 3, 8, and 9 were the most active compounds (EC90/MIC1). Also, the cytotoxic effects indicate that these compounds have a good Selectivity Index (SI)." @default.
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• W2029685741 date "2003-05-01" @default.
• W2029685741 modified "2023-10-15" @default.
• W2029685741 title "Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-Oxide derivatives" @default.
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• W2029685741 doi "https://doi.org/10.1016/s0968-0896(03)00119-6" @default.
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