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- W2029687316 abstract "The effect of the central administration of nitroglycerin, a potent organic nibate vasodilator, on penile erection and yawning was studied in male rats. When given intracerebroventriculary (ICV), nitroglycerin (33–99 μg) induced the above responses dose-dependently. The minimal effective dose was 33 μg, which was active in 60% of the rats. Nitroglycerin (1.86–6.6 μg) induced penile erection and yawning also when injected in the paraventricular nucleus of the hypothalamus. Nitroglycerin responses were prevented by methylens blue (200–400 μg ICV), by d(CH2)5Tyr(Me2-Orn8-vaaotocin (0.5–1 μg ICV but not hemoglobin (100–200 μg ICV). In contrast methylene blue (10–20 μg), d(CH2)5Tyr(Me)2-Orn8-vasotocin (0.05–0.1 μg) and hemogiobin (10–20 μg) were ineffective when injected in the paraventricular nucleus. Systemic haloperidol (0.5–1 mg1kg IP) was also ineffective. The results suggest that nitroglycerin induces penile erection and yawning by activef brain oxytocinergic transmission through the formation of nitric oxide in the paraventricular nucleus of the hypothalamus." @default.
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- W2029687316 title "Nitroglycerin-induced penile erection and yawning in male rats: Mechanism of action in the brain" @default.
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- W2029687316 doi "https://doi.org/10.1016/0361-9230(94)00236-t" @default.
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