Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029687716> ?p ?o ?g. }
- W2029687716 endingPage "1060" @default.
- W2029687716 startingPage "1050" @default.
- W2029687716 abstract "DNA methylation is a conserved epigenetic gene-regulation mechanism. DOMAINS REARRANGED METHYLTRANSFERASE (DRM) is a key de novo methyltransferase in plants, but how DRM acts mechanistically is poorly understood. Here, we report the crystal structure of the methyltransferase domain of tobacco DRM (NtDRM) and reveal a molecular basis for its rearranged structure. NtDRM forms a functional homodimer critical for catalytic activity. We also show that Arabidopsis DRM2 exists in complex with the small interfering RNA (siRNA) effector ARGONAUTE4 (AGO4) and preferentially methylates one DNA strand, likely the strand acting as the template for RNA polymerase V-mediated noncoding RNA transcripts. This strand-biased DNA methylation is also positively correlated with strand-biased siRNA accumulation. These data suggest a model in which DRM2 is guided to target loci by AGO4-siRNA and involves base-pairing of associated siRNAs with nascent RNA transcripts." @default.
- W2029687716 created "2016-06-24" @default.
- W2029687716 creator A5003016098 @default.
- W2029687716 creator A5005240902 @default.
- W2029687716 creator A5006474948 @default.
- W2029687716 creator A5016220698 @default.
- W2029687716 creator A5022888501 @default.
- W2029687716 creator A5046148857 @default.
- W2029687716 creator A5054350125 @default.
- W2029687716 creator A5058024620 @default.
- W2029687716 creator A5077706769 @default.
- W2029687716 creator A5086958208 @default.
- W2029687716 date "2014-05-01" @default.
- W2029687716 modified "2023-10-14" @default.
- W2029687716 title "Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases" @default.
- W2029687716 cites W1500702901 @default.
- W2029687716 cites W1539796472 @default.
- W2029687716 cites W1976600101 @default.
- W2029687716 cites W1977171359 @default.
- W2029687716 cites W1981276210 @default.
- W2029687716 cites W1983910249 @default.
- W2029687716 cites W1984251741 @default.
- W2029687716 cites W1986191025 @default.
- W2029687716 cites W1989568035 @default.
- W2029687716 cites W1994162276 @default.
- W2029687716 cites W2002815900 @default.
- W2029687716 cites W2016246105 @default.
- W2029687716 cites W2016813268 @default.
- W2029687716 cites W2020173141 @default.
- W2029687716 cites W2026343134 @default.
- W2029687716 cites W2039330897 @default.
- W2029687716 cites W2056196527 @default.
- W2029687716 cites W2059099579 @default.
- W2029687716 cites W2060586846 @default.
- W2029687716 cites W2060799753 @default.
- W2029687716 cites W2067151470 @default.
- W2029687716 cites W2068634134 @default.
- W2029687716 cites W2070062799 @default.
- W2029687716 cites W2076533384 @default.
- W2029687716 cites W2089417246 @default.
- W2029687716 cites W2095359906 @default.
- W2029687716 cites W2100071542 @default.
- W2029687716 cites W2106889224 @default.
- W2029687716 cites W2107314112 @default.
- W2029687716 cites W2123921804 @default.
- W2029687716 cites W2124026197 @default.
- W2029687716 cites W2133377110 @default.
- W2029687716 cites W2141429272 @default.
- W2029687716 cites W2148954829 @default.
- W2029687716 cites W2165941008 @default.
- W2029687716 cites W2166795672 @default.
- W2029687716 cites W2180229411 @default.
- W2029687716 doi "https://doi.org/10.1016/j.cell.2014.03.056" @default.
- W2029687716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4123750" @default.
- W2029687716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24855943" @default.
- W2029687716 hasPublicationYear "2014" @default.
- W2029687716 type Work @default.
- W2029687716 sameAs 2029687716 @default.
- W2029687716 citedByCount "226" @default.
- W2029687716 countsByYear W20296877162014 @default.
- W2029687716 countsByYear W20296877162015 @default.
- W2029687716 countsByYear W20296877162016 @default.
- W2029687716 countsByYear W20296877162017 @default.
- W2029687716 countsByYear W20296877162018 @default.
- W2029687716 countsByYear W20296877162019 @default.
- W2029687716 countsByYear W20296877162020 @default.
- W2029687716 countsByYear W20296877162021 @default.
- W2029687716 countsByYear W20296877162022 @default.
- W2029687716 countsByYear W20296877162023 @default.
- W2029687716 crossrefType "journal-article" @default.
- W2029687716 hasAuthorship W2029687716A5003016098 @default.
- W2029687716 hasAuthorship W2029687716A5005240902 @default.
- W2029687716 hasAuthorship W2029687716A5006474948 @default.
- W2029687716 hasAuthorship W2029687716A5016220698 @default.
- W2029687716 hasAuthorship W2029687716A5022888501 @default.
- W2029687716 hasAuthorship W2029687716A5046148857 @default.
- W2029687716 hasAuthorship W2029687716A5054350125 @default.
- W2029687716 hasAuthorship W2029687716A5058024620 @default.
- W2029687716 hasAuthorship W2029687716A5077706769 @default.
- W2029687716 hasAuthorship W2029687716A5086958208 @default.
- W2029687716 hasBestOaLocation W20296877161 @default.
- W2029687716 hasConcept C104317684 @default.
- W2029687716 hasConcept C150194340 @default.
- W2029687716 hasConcept C153911025 @default.
- W2029687716 hasConcept C163002167 @default.
- W2029687716 hasConcept C185581394 @default.
- W2029687716 hasConcept C190727270 @default.
- W2029687716 hasConcept C201853390 @default.
- W2029687716 hasConcept C22615655 @default.
- W2029687716 hasConcept C2779979206 @default.
- W2029687716 hasConcept C33288867 @default.
- W2029687716 hasConcept C41091548 @default.
- W2029687716 hasConcept C54355233 @default.
- W2029687716 hasConcept C552990157 @default.
- W2029687716 hasConcept C60723119 @default.
- W2029687716 hasConcept C62203573 @default.
- W2029687716 hasConcept C67705224 @default.
- W2029687716 hasConcept C86803240 @default.