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- W2029698932 abstract "A double-blind study was made to test the comparative value of four antiemetic drugs in preventing postoperative nausea and vomiting. A total of 3,454 patients were studied. Of these, 1,114 received nothing, 367 received a placebo, 754 received triflupromazine, 537 received cyclizine, 442 received fluphenazine, and 240 received promethazine. It is probable that there was no placebo response in these studies, since most of the patients were unconscious when the test drug was administered. Cyclizine was more effective than the placebo, but the phenothiazine compounds were significantly more effective than either in reducing the percentage of awake patients who reported nausea. Promethazine and triflupromazine significantly prolonged postanesthetic sleep. Unlike doses of fluphenazine and promethazine, doses in excess of 7.5 mg. of triflupromazine produced significant hypotensive side-effects." @default.
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- W2029698932 date "1960-04-02" @default.
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- W2029698932 title "POSTOPERATIVE NAUSEA AND VOMITING" @default.
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- W2029698932 doi "https://doi.org/10.1001/jama.1960.03020140024006" @default.
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