FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029703138> ?p ?o ?g. }

• W2029703138 endingPage "70" @default.
• W2029703138 startingPage "62" @default.
• W2029703138 abstract "We used a flexibly mounted microdialysis technique to the hearts of rats and examined the protective effect of imidaprilat, an angiotensin-converting enzyme (ACE) inhibitor, on the production of hydroxyl free radical (*OH) generation. A microdialysis probe was implanted into the left ventricular myocardium, and dialysate norepinephrine (NE) concentrations were measured as an index of myocardial interstitial NE levels. Sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was directly infused through a microdialysis probe to detect the generation of *OH reflected by the formation of dihydroxybenzoic acid (DHBA) in rat myocardium. When tyramine (1 mM) was directly infused through the microdialysis probe, the level of NE significantly increased in the dialysate and the level of NE increased by 128 +/- 43%. Imidaprilat (5, 25 and 50 microM) decreased the level of tyramine (1 mM)-induced NE in a concentration-dependent manner. Tyramine clearly produced an increase in *OH formation. In the presence of imidaprilat (50 microM), tyramine failed to increase both 2,3- and 2,5-dihydroxylation. Therefore, the effects of imidaprilat on the *OH generation in the sympathetic nerve blockaded hearts by reserpine treatment were not observed. Moreover, to examine the effect of imidaprilat on *OH formation by ischemia/reperfusion of the myocardium, the heart was subjected to myocardial ischemia for 15 min by occlusion of the left anterior descending coronary artery. When the heart was reperfused, elevation of NE and 2,3- and 2,5-DHBA in imidaprilat (50 microM)-pretreated animals was not observed in the heart dialysate. Imidaprilat 2.5 mg/kg i.p. pretreatment at 5 h before coronary occlusion significantly blunted the rise of serum creatine phosphokinase and improved the electrocardiogram 2 h after coronary occlusion. These results suggest that imidaprilat, an ACE inhibitor, is associated with cardioprotective effect due to the suppression of NE-induced *OH generation." @default.
• W2029703138 created "2016-06-24" @default.
• W2029703138 creator A5009113447 @default.
• W2029703138 creator A5023328943 @default.
• W2029703138 date "1999-10-01" @default.
• W2029703138 modified "2023-09-29" @default.
• W2029703138 title "Protective effect of imidaprilat, an angiotensin-converting enzyme inhibitor on ⋅OH generation in rat myocardium" @default.
• W2029703138 cites W1964685161 @default.
• W2029703138 cites W1978584900 @default.
• W2029703138 cites W1983500255 @default.
• W2029703138 cites W1984202672 @default.
• W2029703138 cites W1985285096 @default.
• W2029703138 cites W1987280431 @default.
• W2029703138 cites W1991201413 @default.
• W2029703138 cites W1992578325 @default.
• W2029703138 cites W2005754114 @default.
• W2029703138 cites W2006775447 @default.
• W2029703138 cites W2009447742 @default.
• W2029703138 cites W2013573272 @default.
• W2029703138 cites W2019382425 @default.
• W2029703138 cites W2024560631 @default.
• W2029703138 cites W2031959501 @default.
• W2029703138 cites W2033168194 @default.
• W2029703138 cites W2034228138 @default.
• W2029703138 cites W2045344901 @default.
• W2029703138 cites W2047861107 @default.
• W2029703138 cites W2049597734 @default.
• W2029703138 cites W2051681090 @default.
• W2029703138 cites W2069593438 @default.
• W2029703138 cites W2073778582 @default.
• W2029703138 cites W2083860016 @default.
• W2029703138 cites W2084299409 @default.
• W2029703138 cites W2085886022 @default.
• W2029703138 cites W2095378987 @default.
• W2029703138 cites W2097744068 @default.
• W2029703138 cites W2112979325 @default.
• W2029703138 cites W2144359724 @default.
• W2029703138 cites W2144633996 @default.
• W2029703138 cites W2163516165 @default.
• W2029703138 cites W2171047055 @default.
• W2029703138 cites W2255872159 @default.
• W2029703138 cites W2259244561 @default.
• W2029703138 cites W2397325884 @default.
• W2029703138 cites W2402421099 @default.
• W2029703138 cites W2403334878 @default.
• W2029703138 cites W2409952048 @default.
• W2029703138 cites W2413654241 @default.
• W2029703138 cites W2416276430 @default.
• W2029703138 cites W2424710255 @default.
• W2029703138 cites W2467414291 @default.
• W2029703138 cites W82191719 @default.
• W2029703138 doi "https://doi.org/10.1016/s0304-4165(99)00104-x" @default.
• W2029703138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10572926" @default.
• W2029703138 hasPublicationYear "1999" @default.
• W2029703138 type Work @default.
• W2029703138 sameAs 2029703138 @default.
• W2029703138 citedByCount "7" @default.
• W2029703138 countsByYear W20297031382012 @default.
• W2029703138 countsByYear W20297031382014 @default.
• W2029703138 countsByYear W20297031382018 @default.
• W2029703138 crossrefType "journal-article" @default.
• W2029703138 hasAuthorship W2029703138A5009113447 @default.
• W2029703138 hasAuthorship W2029703138A5023328943 @default.
• W2029703138 hasConcept C126322002 @default.
• W2029703138 hasConcept C134018914 @default.
• W2029703138 hasConcept C185592680 @default.
• W2029703138 hasConcept C2776077682 @default.
• W2029703138 hasConcept C2778514916 @default.
• W2029703138 hasConcept C28406088 @default.
• W2029703138 hasConcept C50156730 @default.
• W2029703138 hasConcept C513476851 @default.
• W2029703138 hasConcept C541997718 @default.
• W2029703138 hasConcept C55493867 @default.
• W2029703138 hasConcept C71924100 @default.
• W2029703138 hasConceptScore W2029703138C126322002 @default.
• W2029703138 hasConceptScore W2029703138C134018914 @default.
• W2029703138 hasConceptScore W2029703138C185592680 @default.
• W2029703138 hasConceptScore W2029703138C2776077682 @default.
• W2029703138 hasConceptScore W2029703138C2778514916 @default.
• W2029703138 hasConceptScore W2029703138C28406088 @default.
• W2029703138 hasConceptScore W2029703138C50156730 @default.
• W2029703138 hasConceptScore W2029703138C513476851 @default.
• W2029703138 hasConceptScore W2029703138C541997718 @default.
• W2029703138 hasConceptScore W2029703138C55493867 @default.
• W2029703138 hasConceptScore W2029703138C71924100 @default.
• W2029703138 hasIssue "1-2" @default.
• W2029703138 hasLocation W20297031381 @default.
• W2029703138 hasLocation W20297031382 @default.
• W2029703138 hasOpenAccess W2029703138 @default.
• W2029703138 hasPrimaryLocation W20297031381 @default.
• W2029703138 hasRelatedWork W1969081729 @default.
• W2029703138 hasRelatedWork W1969640580 @default.
• W2029703138 hasRelatedWork W1974907526 @default.
• W2029703138 hasRelatedWork W1995853913 @default.
• W2029703138 hasRelatedWork W2003797084 @default.
• W2029703138 hasRelatedWork W2029739536 @default.
• W2029703138 hasRelatedWork W2088043612 @default.
• W2029703138 hasRelatedWork W2089926309 @default.

• next