FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029704355> ?p ?o ?g. }

• W2029704355 endingPage "919" @default.
• W2029704355 startingPage "909" @default.
• W2029704355 abstract "Cross-presentation is an important function of immune competent cells, such as dendritic cells (DCs), macrophages, and an organ-resident liver cell population, i.e., liver sinusoidal endothelial cells (LSECs). Here, we characterize in direct comparison to DCs the distinct dynamics and kinetics of cross-presentation employed by LSECs, which promote tolerance induction in CD8 T cells. We found that LSECs were as competent in cross-presenting circulating soluble antigen ex vivo as DCs at a per-cell basis. However, antigen uptake in vivo was 100-fold more pronounced in LSECs, indicating distinct mechanisms of cross-presentation. In contrast to mannose-receptor–mediated antigen uptake and routing into stable endosomes dedicated to cross-presentation in DCs, we observed distinct antigen-uptake and endosomal routing with high antigen turnover in LSECs that resulted in short-lived cross-presentation. Receptor-mediated endocytosis did not always lead to cross-presentation, because immune-complexed antigen taken up by the Fc-receptor was not cross-presented by LSECs, indicating that induction of CD8 T cell tolerance by LSECs is impaired in the presence of preexisting immunity. Conclusion: These results provide a mechanistic explanation how organ-resident LSECs accommodate continuous scavenger function with the capacity to cross-present circulating antigens using distinct kinetics and dynamics of antigen-uptake, routing and cross-presentation compared to DCs. (HEPATOLOGY 2009.)" @default.
• W2029704355 created "2016-06-24" @default.
• W2029704355 creator A5031622132 @default.
• W2029704355 creator A5034061948 @default.
• W2029704355 creator A5034883475 @default.
• W2029704355 creator A5037625387 @default.
• W2029704355 creator A5042316785 @default.
• W2029704355 creator A5059931392 @default.
• W2029704355 creator A5068960230 @default.
• W2029704355 creator A5069739324 @default.
• W2029704355 creator A5071291097 @default.
• W2029704355 creator A5073349155 @default.
• W2029704355 creator A5075113645 @default.
• W2029704355 creator A5075167876 @default.
• W2029704355 creator A5080657202 @default.
• W2029704355 date "2009-05-11" @default.
• W2029704355 modified "2023-09-25" @default.
• W2029704355 title "Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells" @default.
• W2029704355 cites W1498929362 @default.
• W2029704355 cites W1584203472 @default.
• W2029704355 cites W1977298268 @default.
• W2029704355 cites W1977402753 @default.
• W2029704355 cites W1977812921 @default.
• W2029704355 cites W1990702740 @default.
• W2029704355 cites W1995332691 @default.
• W2029704355 cites W1997276741 @default.
• W2029704355 cites W2019977471 @default.
• W2029704355 cites W2023545075 @default.
• W2029704355 cites W2038963303 @default.
• W2029704355 cites W2048143404 @default.
• W2029704355 cites W2051731494 @default.
• W2029704355 cites W2052588752 @default.
• W2029704355 cites W2053565314 @default.
• W2029704355 cites W2057955349 @default.
• W2029704355 cites W2064773757 @default.
• W2029704355 cites W2065707764 @default.
• W2029704355 cites W2068206773 @default.
• W2029704355 cites W2072679758 @default.
• W2029704355 cites W2075901113 @default.
• W2029704355 cites W2081287274 @default.
• W2029704355 cites W2108765339 @default.
• W2029704355 cites W2110365405 @default.
• W2029704355 cites W2127036601 @default.
• W2029704355 cites W2130867278 @default.
• W2029704355 cites W2131000952 @default.
• W2029704355 cites W2134250807 @default.
• W2029704355 cites W2142804723 @default.
• W2029704355 cites W2146220880 @default.
• W2029704355 cites W2154792422 @default.
• W2029704355 cites W2159164156 @default.
• W2029704355 cites W2168400876 @default.
• W2029704355 cites W2169528038 @default.
• W2029704355 cites W3153504824 @default.
• W2029704355 doi "https://doi.org/10.1002/hep.23075" @default.
• W2029704355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19610048" @default.
• W2029704355 hasPublicationYear "2009" @default.
• W2029704355 type Work @default.
• W2029704355 sameAs 2029704355 @default.
• W2029704355 citedByCount "70" @default.
• W2029704355 countsByYear W20297043552012 @default.
• W2029704355 countsByYear W20297043552013 @default.
• W2029704355 countsByYear W20297043552014 @default.
• W2029704355 countsByYear W20297043552015 @default.
• W2029704355 countsByYear W20297043552016 @default.
• W2029704355 countsByYear W20297043552017 @default.
• W2029704355 countsByYear W20297043552018 @default.
• W2029704355 countsByYear W20297043552019 @default.
• W2029704355 countsByYear W20297043552020 @default.
• W2029704355 countsByYear W20297043552021 @default.
• W2029704355 countsByYear W20297043552022 @default.
• W2029704355 countsByYear W20297043552023 @default.
• W2029704355 crossrefType "journal-article" @default.
• W2029704355 hasAuthorship W2029704355A5031622132 @default.
• W2029704355 hasAuthorship W2029704355A5034061948 @default.
• W2029704355 hasAuthorship W2029704355A5034883475 @default.
• W2029704355 hasAuthorship W2029704355A5037625387 @default.
• W2029704355 hasAuthorship W2029704355A5042316785 @default.
• W2029704355 hasAuthorship W2029704355A5059931392 @default.
• W2029704355 hasAuthorship W2029704355A5068960230 @default.
• W2029704355 hasAuthorship W2029704355A5069739324 @default.
• W2029704355 hasAuthorship W2029704355A5071291097 @default.
• W2029704355 hasAuthorship W2029704355A5073349155 @default.
• W2029704355 hasAuthorship W2029704355A5075113645 @default.
• W2029704355 hasAuthorship W2029704355A5075167876 @default.
• W2029704355 hasAuthorship W2029704355A5080657202 @default.
• W2029704355 hasConcept C147483822 @default.
• W2029704355 hasConcept C167672396 @default.
• W2029704355 hasConcept C203014093 @default.
• W2029704355 hasConcept C2776090121 @default.
• W2029704355 hasConcept C2778170410 @default.
• W2029704355 hasConcept C2778973524 @default.
• W2029704355 hasConcept C67662055 @default.
• W2029704355 hasConcept C83464605 @default.
• W2029704355 hasConcept C86803240 @default.
• W2029704355 hasConcept C8891405 @default.
• W2029704355 hasConcept C95444343 @default.
• W2029704355 hasConceptScore W2029704355C147483822 @default.
• W2029704355 hasConceptScore W2029704355C167672396 @default.

• next