Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029706058> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2029706058 endingPage "5700" @default.
- W2029706058 startingPage "5695" @default.
- W2029706058 abstract "Glioma is the most common of brain tumors that greatly affects patient survival. In our precious study, Crk-like adapter protein (CrkL) was identified as a key regulator in glioblastoma development [1]. Here, we aimed to investigate the correlation of CrkL with patient prognosis as well as pathological indicators. Immunohistochemistry was available to evaluate CrkL expression in 49 gliomas of distinct malignancy grade, and positive stained sites were analyzed. CrkL protein was detected in cell lines by Western blot as well. We observed CrkL protein stained in 59.2 % (29 out of 49) of all glioma tissues, including 41.4 % of low-grade (I + II) gliomas, and 85.0 % of high-grade (III + IV) gliomas. Of four grades, grade IV exhibited the highest CrkL level. CrkL protein was also identified in cell lines NHA, U87, U251, T98G, and A172 by Western blot. On the other hand, CrkL expression was significantly associated with the patient’s age and WHO grade, and patients with high CrkL expression had a significantly shorter median survival time (17 months) than those (median survival time 52 months) with low CrkL expression (p < 0.001). According to Cox regression, CrkL can be suggested as an independent prognostic factor. In conclusion, CrkL is differently expressed in different grades of gliomas, and correlated to WHO grade. CrkL also independently indicates poor prognosis in old glioma patients, which can further be recommended as an effective prognostic biomarker or therapeutic target." @default.
- W2029706058 created "2016-06-24" @default.
- W2029706058 creator A5011184859 @default.
- W2029706058 creator A5042525407 @default.
- W2029706058 creator A5055355902 @default.
- W2029706058 creator A5063466446 @default.
- W2029706058 creator A5066716873 @default.
- W2029706058 creator A5072280652 @default.
- W2029706058 creator A5073501391 @default.
- W2029706058 creator A5083356558 @default.
- W2029706058 creator A5089820455 @default.
- W2029706058 date "2014-02-22" @default.
- W2029706058 modified "2023-10-06" @default.
- W2029706058 title "The association of Crk-like adapter protein with poor prognosis in glioma patients" @default.
- W2029706058 cites W1521026010 @default.
- W2029706058 cites W1970551371 @default.
- W2029706058 cites W1976918795 @default.
- W2029706058 cites W2007890109 @default.
- W2029706058 cites W2025504334 @default.
- W2029706058 cites W2035593440 @default.
- W2029706058 cites W2055475004 @default.
- W2029706058 cites W2057603067 @default.
- W2029706058 cites W2066359023 @default.
- W2029706058 cites W2075099549 @default.
- W2029706058 cites W2080605787 @default.
- W2029706058 cites W2089064510 @default.
- W2029706058 cites W2103563973 @default.
- W2029706058 cites W2148014571 @default.
- W2029706058 cites W2149532912 @default.
- W2029706058 cites W2160315153 @default.
- W2029706058 cites W2163274936 @default.
- W2029706058 cites W2167903227 @default.
- W2029706058 cites W2080920726 @default.
- W2029706058 doi "https://doi.org/10.1007/s13277-014-1754-y" @default.
- W2029706058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24563280" @default.
- W2029706058 hasPublicationYear "2014" @default.
- W2029706058 type Work @default.
- W2029706058 sameAs 2029706058 @default.
- W2029706058 citedByCount "4" @default.
- W2029706058 countsByYear W20297060582014 @default.
- W2029706058 countsByYear W20297060582015 @default.
- W2029706058 countsByYear W20297060582018 @default.
- W2029706058 crossrefType "journal-article" @default.
- W2029706058 hasAuthorship W2029706058A5011184859 @default.
- W2029706058 hasAuthorship W2029706058A5042525407 @default.
- W2029706058 hasAuthorship W2029706058A5055355902 @default.
- W2029706058 hasAuthorship W2029706058A5063466446 @default.
- W2029706058 hasAuthorship W2029706058A5066716873 @default.
- W2029706058 hasAuthorship W2029706058A5072280652 @default.
- W2029706058 hasAuthorship W2029706058A5073501391 @default.
- W2029706058 hasAuthorship W2029706058A5083356558 @default.
- W2029706058 hasAuthorship W2029706058A5089820455 @default.
- W2029706058 hasConcept C104317684 @default.
- W2029706058 hasConcept C126322002 @default.
- W2029706058 hasConcept C133570447 @default.
- W2029706058 hasConcept C143998085 @default.
- W2029706058 hasConcept C170493617 @default.
- W2029706058 hasConcept C183786373 @default.
- W2029706058 hasConcept C204232928 @default.
- W2029706058 hasConcept C2776415932 @default.
- W2029706058 hasConcept C2778227246 @default.
- W2029706058 hasConcept C502942594 @default.
- W2029706058 hasConcept C55493867 @default.
- W2029706058 hasConcept C71924100 @default.
- W2029706058 hasConcept C86803240 @default.
- W2029706058 hasConceptScore W2029706058C104317684 @default.
- W2029706058 hasConceptScore W2029706058C126322002 @default.
- W2029706058 hasConceptScore W2029706058C133570447 @default.
- W2029706058 hasConceptScore W2029706058C143998085 @default.
- W2029706058 hasConceptScore W2029706058C170493617 @default.
- W2029706058 hasConceptScore W2029706058C183786373 @default.
- W2029706058 hasConceptScore W2029706058C204232928 @default.
- W2029706058 hasConceptScore W2029706058C2776415932 @default.
- W2029706058 hasConceptScore W2029706058C2778227246 @default.
- W2029706058 hasConceptScore W2029706058C502942594 @default.
- W2029706058 hasConceptScore W2029706058C55493867 @default.
- W2029706058 hasConceptScore W2029706058C71924100 @default.
- W2029706058 hasConceptScore W2029706058C86803240 @default.
- W2029706058 hasIssue "6" @default.
- W2029706058 hasLocation W20297060581 @default.
- W2029706058 hasLocation W20297060582 @default.
- W2029706058 hasOpenAccess W2029706058 @default.
- W2029706058 hasPrimaryLocation W20297060581 @default.
- W2029706058 hasRelatedWork W1466030670 @default.
- W2029706058 hasRelatedWork W2007846116 @default.
- W2029706058 hasRelatedWork W2029706058 @default.
- W2029706058 hasRelatedWork W2052597531 @default.
- W2029706058 hasRelatedWork W2073311278 @default.
- W2029706058 hasRelatedWork W2203548424 @default.
- W2029706058 hasRelatedWork W2338623289 @default.
- W2029706058 hasRelatedWork W2348859211 @default.
- W2029706058 hasRelatedWork W2361614602 @default.
- W2029706058 hasRelatedWork W3003359890 @default.
- W2029706058 hasVolume "35" @default.
- W2029706058 isParatext "false" @default.
- W2029706058 isRetracted "true" @default.
- W2029706058 magId "2029706058" @default.
- W2029706058 workType "article" @default.