Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029708405> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2029708405 endingPage "955" @default.
- W2029708405 startingPage "949" @default.
- W2029708405 abstract "The human phosphoglycerate kinase (Pgk) gene family includes the functional, intronless Pgk-2 gene and the intronless psi hPgk-1 pseudogene, both of which are retroposons of the intron-containing Pgk-1 gene. The divergence of the Pgk-2 retroposon from Pgk-1 is compared with that of the psi hPgk-1 retroposon from Pgk-1 to reveal nucleotide characteristics diagnostic of functional genes. A comparison of the human and mouse Pgk genes indicates that Pgk-2 has evolved more rapidly than Pgk-1 since the two genes diverged early in mammalian evolution, but that the lack of introns in Pgk-2 may have diminished inter-exon variation. The hypothesis that codon bias is related to expression level is shown not to hold for the Pgk genes; however, the idea that a deficiency of TA and CG dinucleotides and an excess of TG and CT dinucleotides contributes to codon bias is supported. Finally, the hypothesis that the Pgk-2 retroposon initially included a copy of the Pgk-1 'housekeeping' promoter and subsequently evolved a tissue-specific promoter is examined and supported. It is concluded that this process involved the loss of the 5' CpG island present in the Pgk-1 gene, and that selection for cell type-specific expression of Pgk-2 at high levels has driven the divergence of this retroposon from its progenitor, Pgk-1." @default.
- W2029708405 created "2016-06-24" @default.
- W2029708405 creator A5039244523 @default.
- W2029708405 date "1990-01-01" @default.
- W2029708405 modified "2023-09-26" @default.
- W2029708405 title "Molecular evolution of the human Pgk-2 retroposon" @default.
- W2029708405 cites W1562372319 @default.
- W2029708405 cites W1603411458 @default.
- W2029708405 cites W1807571042 @default.
- W2029708405 cites W1878315031 @default.
- W2029708405 cites W1951333111 @default.
- W2029708405 cites W1973304749 @default.
- W2029708405 cites W1980678647 @default.
- W2029708405 cites W1991480269 @default.
- W2029708405 cites W1992129753 @default.
- W2029708405 cites W1993298572 @default.
- W2029708405 cites W2005121049 @default.
- W2029708405 cites W2005672514 @default.
- W2029708405 cites W2008226850 @default.
- W2029708405 cites W2012911917 @default.
- W2029708405 cites W2027059027 @default.
- W2029708405 cites W2033145713 @default.
- W2029708405 cites W2034105248 @default.
- W2029708405 cites W2045115182 @default.
- W2029708405 cites W2051043527 @default.
- W2029708405 cites W2055292695 @default.
- W2029708405 cites W2059914212 @default.
- W2029708405 cites W2063955247 @default.
- W2029708405 cites W2070389401 @default.
- W2029708405 cites W2073351208 @default.
- W2029708405 cites W2077245645 @default.
- W2029708405 cites W2084748297 @default.
- W2029708405 cites W2091595679 @default.
- W2029708405 cites W2164618276 @default.
- W2029708405 cites W261410759 @default.
- W2029708405 doi "https://doi.org/10.1093/nar/18.4.949" @default.
- W2029708405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/330349" @default.
- W2029708405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2156237" @default.
- W2029708405 hasPublicationYear "1990" @default.
- W2029708405 type Work @default.
- W2029708405 sameAs 2029708405 @default.
- W2029708405 citedByCount "53" @default.
- W2029708405 countsByYear W20297084052012 @default.
- W2029708405 countsByYear W20297084052013 @default.
- W2029708405 countsByYear W20297084052014 @default.
- W2029708405 countsByYear W20297084052017 @default.
- W2029708405 crossrefType "journal-article" @default.
- W2029708405 hasAuthorship W2029708405A5039244523 @default.
- W2029708405 hasBestOaLocation W20297084052 @default.
- W2029708405 hasConcept C104317684 @default.
- W2029708405 hasConcept C141231307 @default.
- W2029708405 hasConcept C155911427 @default.
- W2029708405 hasConcept C34957205 @default.
- W2029708405 hasConcept C4918238 @default.
- W2029708405 hasConcept C54355233 @default.
- W2029708405 hasConcept C86803240 @default.
- W2029708405 hasConcept C87578298 @default.
- W2029708405 hasConcept C94671646 @default.
- W2029708405 hasConceptScore W2029708405C104317684 @default.
- W2029708405 hasConceptScore W2029708405C141231307 @default.
- W2029708405 hasConceptScore W2029708405C155911427 @default.
- W2029708405 hasConceptScore W2029708405C34957205 @default.
- W2029708405 hasConceptScore W2029708405C4918238 @default.
- W2029708405 hasConceptScore W2029708405C54355233 @default.
- W2029708405 hasConceptScore W2029708405C86803240 @default.
- W2029708405 hasConceptScore W2029708405C87578298 @default.
- W2029708405 hasConceptScore W2029708405C94671646 @default.
- W2029708405 hasIssue "4" @default.
- W2029708405 hasLocation W20297084051 @default.
- W2029708405 hasLocation W20297084052 @default.
- W2029708405 hasLocation W20297084053 @default.
- W2029708405 hasLocation W20297084054 @default.
- W2029708405 hasOpenAccess W2029708405 @default.
- W2029708405 hasPrimaryLocation W20297084051 @default.
- W2029708405 hasRelatedWork W1971010738 @default.
- W2029708405 hasRelatedWork W2005672514 @default.
- W2029708405 hasRelatedWork W2007559212 @default.
- W2029708405 hasRelatedWork W2018135334 @default.
- W2029708405 hasRelatedWork W2060631033 @default.
- W2029708405 hasRelatedWork W2072414523 @default.
- W2029708405 hasRelatedWork W2082451158 @default.
- W2029708405 hasRelatedWork W2092554027 @default.
- W2029708405 hasRelatedWork W2167692816 @default.
- W2029708405 hasRelatedWork W4242521457 @default.
- W2029708405 hasVolume "18" @default.
- W2029708405 isParatext "false" @default.
- W2029708405 isRetracted "false" @default.
- W2029708405 magId "2029708405" @default.
- W2029708405 workType "article" @default.