Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029708652> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2029708652 endingPage "540" @default.
- W2029708652 startingPage "535" @default.
- W2029708652 abstract "A 20-year-old mentally retarded male with pyroglutamic aciduria has recently been described. The laboratory findings in this disorder are a high pyroglutamic acid (pyrrolidone-2-carboxylic acid) excretion (25–35 g/24 h), low excretion of urea (5–10 g/24 h) and metabolic acidosis. The serum and the cerebrospinal fluid contain 5 and 30 mg/100 ml, respectively, of pyroglutamic acid. The serum level of proline is 3 times the normal. Biochemical studies of the disorder show that (a) the patient converts ammonia to urea in a normal manner and responds normally to a high-calorie, low-protein diet. (b) A correlation exists between urinary ammonia and pyroglutamic acid, the excretion of both being independent of urinary pH. (c) Neither glutamine nor glutamic acid are direct precursors of pyroglutamic acid. (d) The patient, in contrast to normals, is unable to hydrolyze pyroglutamic acid to glutamic acid, (e) That i.v. infusion of amino acids to the patient is the only condition found which significantly increases the excretion of pyroglutamic acid.These studies indicate that pyroglutamate is involved in the renal handling of amino acids, and that the patient has a block in one of the steps (pyroglutamic acid to glutamic acid) of the γ-glutamyl cycle proposed by Orlowski and Meister." @default.
- W2029708652 created "2016-06-24" @default.
- W2029708652 creator A5021262070 @default.
- W2029708652 creator A5080663815 @default.
- W2029708652 date "1964-08-01" @default.
- W2029708652 modified "2023-10-10" @default.
- W2029708652 title "Energy production and pyrrolidonecarboxylic acid formation in rat liver nuclei" @default.
- W2029708652 cites W1775749144 @default.
- W2029708652 cites W182913924 @default.
- W2029708652 cites W1854714297 @default.
- W2029708652 cites W2027914762 @default.
- W2029708652 cites W2071044672 @default.
- W2029708652 cites W2078402237 @default.
- W2029708652 cites W2078533553 @default.
- W2029708652 cites W2082508679 @default.
- W2029708652 cites W2089442156 @default.
- W2029708652 cites W2125962904 @default.
- W2029708652 cites W2277414274 @default.
- W2029708652 doi "https://doi.org/10.1016/0006-291x(64)90188-3" @default.
- W2029708652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5871844" @default.
- W2029708652 hasPublicationYear "1964" @default.
- W2029708652 type Work @default.
- W2029708652 sameAs 2029708652 @default.
- W2029708652 citedByCount "11" @default.
- W2029708652 crossrefType "journal-article" @default.
- W2029708652 hasAuthorship W2029708652A5021262070 @default.
- W2029708652 hasAuthorship W2029708652A5080663815 @default.
- W2029708652 hasConcept C10146269 @default.
- W2029708652 hasConcept C126322002 @default.
- W2029708652 hasConcept C134018914 @default.
- W2029708652 hasConcept C185592680 @default.
- W2029708652 hasConcept C2776382133 @default.
- W2029708652 hasConcept C2777468819 @default.
- W2029708652 hasConcept C2777927761 @default.
- W2029708652 hasConcept C2778740566 @default.
- W2029708652 hasConcept C2779246250 @default.
- W2029708652 hasConcept C2779349466 @default.
- W2029708652 hasConcept C2780365088 @default.
- W2029708652 hasConcept C515207424 @default.
- W2029708652 hasConcept C55493867 @default.
- W2029708652 hasConcept C71924100 @default.
- W2029708652 hasConcept C77061444 @default.
- W2029708652 hasConceptScore W2029708652C10146269 @default.
- W2029708652 hasConceptScore W2029708652C126322002 @default.
- W2029708652 hasConceptScore W2029708652C134018914 @default.
- W2029708652 hasConceptScore W2029708652C185592680 @default.
- W2029708652 hasConceptScore W2029708652C2776382133 @default.
- W2029708652 hasConceptScore W2029708652C2777468819 @default.
- W2029708652 hasConceptScore W2029708652C2777927761 @default.
- W2029708652 hasConceptScore W2029708652C2778740566 @default.
- W2029708652 hasConceptScore W2029708652C2779246250 @default.
- W2029708652 hasConceptScore W2029708652C2779349466 @default.
- W2029708652 hasConceptScore W2029708652C2780365088 @default.
- W2029708652 hasConceptScore W2029708652C515207424 @default.
- W2029708652 hasConceptScore W2029708652C55493867 @default.
- W2029708652 hasConceptScore W2029708652C71924100 @default.
- W2029708652 hasConceptScore W2029708652C77061444 @default.
- W2029708652 hasIssue "6" @default.
- W2029708652 hasLocation W20297086521 @default.
- W2029708652 hasLocation W20297086522 @default.
- W2029708652 hasOpenAccess W2029708652 @default.
- W2029708652 hasPrimaryLocation W20297086521 @default.
- W2029708652 hasRelatedWork W1539114463 @default.
- W2029708652 hasRelatedWork W2017189186 @default.
- W2029708652 hasRelatedWork W2038358091 @default.
- W2029708652 hasRelatedWork W2056080183 @default.
- W2029708652 hasRelatedWork W2085264620 @default.
- W2029708652 hasRelatedWork W2318140687 @default.
- W2029708652 hasRelatedWork W2419371428 @default.
- W2029708652 hasRelatedWork W2894466860 @default.
- W2029708652 hasRelatedWork W4210501339 @default.
- W2029708652 hasRelatedWork W1044687680 @default.
- W2029708652 hasVolume "16" @default.
- W2029708652 isParatext "false" @default.
- W2029708652 isRetracted "false" @default.
- W2029708652 magId "2029708652" @default.
- W2029708652 workType "article" @default.