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- W2029713057 abstract "This study examines the ability of Arctic charr (Salvelinus alpinus) embryos to metabolize tritiated androstenedione (A4), testosterone (T), 17β-estradiol (E2), and estrone (E1)in vitro;the metabolic products were separated by HPLC. A4was poorly metabolized, with 48 to 64% of the substrate remaining even after 24 hr of incubation. The major metabolites of A4metabolism are E1and some other unidentified metabolites. T was mostly converted to A4, along with some reduced steroids, but E2was a minor metabolite. Further, while E2was almost exclusively transformed into E1, when E1was used as the precursor, there was little metabolism; the products of E1metabolism were small amounts of E1sulfate, glucuronide, E2, and an unknown metabolite which cochromatographed with reference steroid androstenetrione (also called 11-ketoandrostenedione). It is concluded that in Arctic charr embryos there is preferential expression of a form of 17β-hydroxysteroid dehydrogenase resembling the type 2 isozyme of mammals that converts T and E2to A4and E1, respectively." @default.
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- W2029713057 date "1997-07-01" @default.
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- W2029713057 title "Metabolism of Estrogens and Androgens by Embryonic Tissues of Arctic Charr,Salvelinus alpinus" @default.
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- W2029713057 doi "https://doi.org/10.1006/gcen.1997.6908" @default.
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