FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029725757> ?p ?o ?g. }

• W2029725757 endingPage "1204" @default.
• W2029725757 startingPage "1196" @default.
• W2029725757 abstract "Background Valvular resistance and stroke work loss have been proposed as alternative measures of stenotic valvular lesions that may be less flow dependent and, thus, superior over valve area calculations for the quantification of aortic stenosis. The present in vitro study was designed to compare the impacts of valvular resistance, stroke work loss, and Gorlin valve area as hemodynamic indexes of aortic stenosis. Methods and Results In a pulsatile aortic flow model, rigid stenotic orifices in varying sizes (0.5, 1.0, 1.5, and 2.0 cm 2 ) and geometry were studied under different hemodynamic conditions. Ventricular and aortic pressures were measured to determine the mean systolic ventricular pressure (LVSP m ) and the transstenotic pressure gradient (ΔP m ). Transvalvular flow (F m ) was assessed with an electromagnetic flowmeter. Valvular resistance [VR=1333 · (ΔP m /F m )] and stroke work loss [SWL=100 · (ΔP m /LVSP m )] were calculated and compared with aortic valve area [AVA=F m /(50√ΔP m )]. The measurements were performed for a large range of transvalvular flows. At low-flow states, flow augmentation (100→200 mL/s) increased calculated valvular resistance between 21% (2.0-cm 2 orifice) and 66% (0.5-cm 2 orifice). Stroke work loss demonstrated an increase from 43% (2.0 cm 2 ) to 100% (1.0 cm 2 ). In contrast, Gorlin valve area revealed only a moderate change from 29% (2.0 cm 2 ) to 5% (0.5 cm 2 ). At physiological flow rates, increase in transvalvular flow (200→300 mL/s) did not alter calculated Gorlin valve area, whereas valvular resistance and stroke work loss demonstrated a continuing increase. Our experimental results were adopted to interpret the results of three clinical studies in aortic stenosis. The flow-dependent increase of Gorlin valve area, which was found in the cited clinical studies, can be elucidated as true further opening of the stenotic valve but not as a calculation error due to the Gorlin formula. Conclusions Within the physiological range of flow, calculated aortic valve area was less dependent on hemodynamic conditions than were valvular resistance and stroke work loss, which varied as a function of flow. Thus, for the assessment of the severity of aortic stenosis, the Gorlin valve area is superior over valvular resistance and stroke work loss, which must be indexed for flow to adequately quantify the hemodynamic severity of the obstruction." @default.
• W2029725757 created "2016-06-24" @default.
• W2029725757 creator A5044492855 @default.
• W2029725757 creator A5047067643 @default.
• W2029725757 creator A5050039208 @default.
• W2029725757 creator A5062533226 @default.
• W2029725757 creator A5071565151 @default.
• W2029725757 creator A5079879196 @default.
• W2029725757 creator A5086275110 @default.
• W2029725757 date "1995-02-15" @default.
• W2029725757 modified "2023-10-10" @default.
• W2029725757 title "Comparison of Valvular Resistance, Stroke Work Loss, and Gorlin Valve Area for Quantification of Aortic Stenosis" @default.
• W2029725757 cites W1963936613 @default.
• W2029725757 cites W1966373079 @default.
• W2029725757 cites W1974593697 @default.
• W2029725757 cites W1985561197 @default.
• W2029725757 cites W1987967218 @default.
• W2029725757 cites W1988368178 @default.
• W2029725757 cites W2004864999 @default.
• W2029725757 cites W2005692641 @default.
• W2029725757 cites W2022569912 @default.
• W2029725757 cites W2024910919 @default.
• W2029725757 cites W2029053486 @default.
• W2029725757 cites W2032737533 @default.
• W2029725757 cites W2042181544 @default.
• W2029725757 cites W2052362924 @default.
• W2029725757 cites W2061658578 @default.
• W2029725757 cites W2065601690 @default.
• W2029725757 cites W2079567320 @default.
• W2029725757 cites W2080037774 @default.
• W2029725757 cites W2081224777 @default.
• W2029725757 cites W2093504056 @default.
• W2029725757 cites W2094271336 @default.
• W2029725757 cites W4321060609 @default.
• W2029725757 doi "https://doi.org/10.1161/01.cir.91.4.1196" @default.
• W2029725757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7850959" @default.
• W2029725757 hasPublicationYear "1995" @default.
• W2029725757 type Work @default.
• W2029725757 sameAs 2029725757 @default.
• W2029725757 citedByCount "78" @default.
• W2029725757 countsByYear W20297257572012 @default.
• W2029725757 countsByYear W20297257572014 @default.
• W2029725757 countsByYear W20297257572015 @default.
• W2029725757 countsByYear W20297257572016 @default.
• W2029725757 countsByYear W20297257572017 @default.
• W2029725757 countsByYear W20297257572018 @default.
• W2029725757 countsByYear W20297257572019 @default.
• W2029725757 countsByYear W20297257572020 @default.
• W2029725757 countsByYear W20297257572021 @default.
• W2029725757 countsByYear W20297257572023 @default.
• W2029725757 crossrefType "journal-article" @default.
• W2029725757 hasAuthorship W2029725757A5044492855 @default.
• W2029725757 hasAuthorship W2029725757A5047067643 @default.
• W2029725757 hasAuthorship W2029725757A5050039208 @default.
• W2029725757 hasAuthorship W2029725757A5062533226 @default.
• W2029725757 hasAuthorship W2029725757A5071565151 @default.
• W2029725757 hasAuthorship W2029725757A5079879196 @default.
• W2029725757 hasAuthorship W2029725757A5086275110 @default.
• W2029725757 hasConcept C126322002 @default.
• W2029725757 hasConcept C127413603 @default.
• W2029725757 hasConcept C164705383 @default.
• W2029725757 hasConcept C178853913 @default.
• W2029725757 hasConcept C2777953023 @default.
• W2029725757 hasConcept C2780007028 @default.
• W2029725757 hasConcept C2780645631 @default.
• W2029725757 hasConcept C2780714102 @default.
• W2029725757 hasConcept C2781414266 @default.
• W2029725757 hasConcept C71924100 @default.
• W2029725757 hasConcept C78519656 @default.
• W2029725757 hasConcept C79191276 @default.
• W2029725757 hasConcept C80461066 @default.
• W2029725757 hasConcept C84393581 @default.
• W2029725757 hasConceptScore W2029725757C126322002 @default.
• W2029725757 hasConceptScore W2029725757C127413603 @default.
• W2029725757 hasConceptScore W2029725757C164705383 @default.
• W2029725757 hasConceptScore W2029725757C178853913 @default.
• W2029725757 hasConceptScore W2029725757C2777953023 @default.
• W2029725757 hasConceptScore W2029725757C2780007028 @default.
• W2029725757 hasConceptScore W2029725757C2780645631 @default.
• W2029725757 hasConceptScore W2029725757C2780714102 @default.
• W2029725757 hasConceptScore W2029725757C2781414266 @default.
• W2029725757 hasConceptScore W2029725757C71924100 @default.
• W2029725757 hasConceptScore W2029725757C78519656 @default.
• W2029725757 hasConceptScore W2029725757C79191276 @default.
• W2029725757 hasConceptScore W2029725757C80461066 @default.
• W2029725757 hasConceptScore W2029725757C84393581 @default.
• W2029725757 hasIssue "4" @default.
• W2029725757 hasLocation W20297257571 @default.
• W2029725757 hasLocation W20297257572 @default.
• W2029725757 hasOpenAccess W2029725757 @default.
• W2029725757 hasPrimaryLocation W20297257571 @default.
• W2029725757 hasRelatedWork W1983749074 @default.
• W2029725757 hasRelatedWork W2014714330 @default.
• W2029725757 hasRelatedWork W2079459316 @default.
• W2029725757 hasRelatedWork W2171696146 @default.
• W2029725757 hasRelatedWork W2391225828 @default.
• W2029725757 hasRelatedWork W2466969129 @default.
• W2029725757 hasRelatedWork W2474193131 @default.

• next