FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029726082> ?p ?o ?g. }

• W2029726082 abstract "Circumstantial evidence suggests that sensitization to the behavioral effects of d-amphetamine is mediated by increased glutamate levels in the ventral tegmental area. To test this directly, the present study examined whether increasing glutamate levels in the ventral tegmental area with a glutamate uptake inhibitor is sufficient, in the absence of d-amphetamine administration, to elicit sensitization to a subsequent d-amphetamine challenge. Rats were treated bilaterally once a day for 2 days with either intra-ventral tegmental area L-trans-pyrollidine-2,4-dicarboxylic acid (50 nmol), saline, L-trans-pyrollidine-2,4-dicarboxylic acid coadministered with the competitive N-methyl-d-aspartate antagonist (+/-)-3-(2-carboxy-piperazin-4-yl)-propyl-1-phosphonic acid; CPP, 0.5 nmol), or CPP alone (0.5 nmol; all 1.0 microl/side). Following a 2 day withdrawal period, all rats were administered systemic d-amphetamine (1 mg/kg, i.p.). Repeated intra-ventral tegmental area injection of L-trans-pyrollidine-2,4-dicarboxylic acid sensitized animals to the behavioral effects of a systemic d-amphetamine challenge, an action which was blocked by co-administration of CPP. The results directly implicate ventral tegmental area glutamate in the process of sensitization to d-amphetamine. Furthermore, they demonstrate that inhibition of glutamate uptake produces the neuroadaptations necessary to induce sensitization, adding support to the contention that d-amphetamine sensitizes by modulating glutamate uptake." @default.
• W2029726082 created "2016-06-24" @default.
• W2029726082 creator A5018136518 @default.
• W2029726082 creator A5023558467 @default.
• W2029726082 creator A5062145914 @default.
• W2029726082 creator A5087325228 @default.
• W2029726082 date "2005-01-01" @default.
• W2029726082 modified "2023-09-28" @default.
• W2029726082 title "Local injection of a glutamate uptake inhibitor into the ventral tegmental area produces sensitization to the behavioural effects of d-amphetamine" @default.
• W2029726082 cites W1537685381 @default.
• W2029726082 cites W1573662382 @default.
• W2029726082 cites W1904399333 @default.
• W2029726082 cites W1958729097 @default.
• W2029726082 cites W1969134234 @default.
• W2029726082 cites W1969761142 @default.
• W2029726082 cites W1999830007 @default.
• W2029726082 cites W2002830117 @default.
• W2029726082 cites W2011963273 @default.
• W2029726082 cites W2018651989 @default.
• W2029726082 cites W2027445806 @default.
• W2029726082 cites W2029997480 @default.
• W2029726082 cites W2031647610 @default.
• W2029726082 cites W2038666297 @default.
• W2029726082 cites W2042200894 @default.
• W2029726082 cites W2048526302 @default.
• W2029726082 cites W2060141808 @default.
• W2029726082 cites W2066144671 @default.
• W2029726082 cites W2071828273 @default.
• W2029726082 cites W2076277826 @default.
• W2029726082 cites W2079112263 @default.
• W2029726082 cites W2084954062 @default.
• W2029726082 cites W2106862702 @default.
• W2029726082 cites W2126624662 @default.
• W2029726082 cites W2163324649 @default.
• W2029726082 cites W2163815564 @default.
• W2029726082 cites W2171539950 @default.
• W2029726082 cites W2217170767 @default.
• W2029726082 doi "https://doi.org/10.1016/j.neuroscience.2005.04.044" @default.
• W2029726082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15975722" @default.
• W2029726082 hasPublicationYear "2005" @default.
• W2029726082 type Work @default.
• W2029726082 sameAs 2029726082 @default.
• W2029726082 citedByCount "8" @default.
• W2029726082 countsByYear W20297260822012 @default.
• W2029726082 countsByYear W20297260822014 @default.
• W2029726082 countsByYear W20297260822016 @default.
• W2029726082 countsByYear W20297260822021 @default.
• W2029726082 crossrefType "journal-article" @default.
• W2029726082 hasAuthorship W2029726082A5018136518 @default.
• W2029726082 hasAuthorship W2029726082A5023558467 @default.
• W2029726082 hasAuthorship W2029726082A5062145914 @default.
• W2029726082 hasAuthorship W2029726082A5087325228 @default.
• W2029726082 hasConcept C126322002 @default.
• W2029726082 hasConcept C137183658 @default.
• W2029726082 hasConcept C169760540 @default.
• W2029726082 hasConcept C170493617 @default.
• W2029726082 hasConcept C185592680 @default.
• W2029726082 hasConcept C2776217527 @default.
• W2029726082 hasConcept C2776552330 @default.
• W2029726082 hasConcept C2777193897 @default.
• W2029726082 hasConcept C2780948874 @default.
• W2029726082 hasConcept C3019662062 @default.
• W2029726082 hasConcept C513476851 @default.
• W2029726082 hasConcept C55493867 @default.
• W2029726082 hasConcept C61174792 @default.
• W2029726082 hasConcept C71924100 @default.
• W2029726082 hasConcept C86803240 @default.
• W2029726082 hasConcept C98274493 @default.
• W2029726082 hasConceptScore W2029726082C126322002 @default.
• W2029726082 hasConceptScore W2029726082C137183658 @default.
• W2029726082 hasConceptScore W2029726082C169760540 @default.
• W2029726082 hasConceptScore W2029726082C170493617 @default.
• W2029726082 hasConceptScore W2029726082C185592680 @default.
• W2029726082 hasConceptScore W2029726082C2776217527 @default.
• W2029726082 hasConceptScore W2029726082C2776552330 @default.
• W2029726082 hasConceptScore W2029726082C2777193897 @default.
• W2029726082 hasConceptScore W2029726082C2780948874 @default.
• W2029726082 hasConceptScore W2029726082C3019662062 @default.
• W2029726082 hasConceptScore W2029726082C513476851 @default.
• W2029726082 hasConceptScore W2029726082C55493867 @default.
• W2029726082 hasConceptScore W2029726082C61174792 @default.
• W2029726082 hasConceptScore W2029726082C71924100 @default.
• W2029726082 hasConceptScore W2029726082C86803240 @default.
• W2029726082 hasConceptScore W2029726082C98274493 @default.
• W2029726082 hasLocation W20297260821 @default.
• W2029726082 hasLocation W20297260822 @default.
• W2029726082 hasOpenAccess W2029726082 @default.
• W2029726082 hasPrimaryLocation W20297260821 @default.
• W2029726082 hasRelatedWork W1970022826 @default.
• W2029726082 hasRelatedWork W1998420008 @default.
• W2029726082 hasRelatedWork W2014095338 @default.
• W2029726082 hasRelatedWork W2023877903 @default.
• W2029726082 hasRelatedWork W2029559798 @default.
• W2029726082 hasRelatedWork W2029726082 @default.
• W2029726082 hasRelatedWork W2059471357 @default.
• W2029726082 hasRelatedWork W2092126179 @default.
• W2029726082 hasRelatedWork W2189338307 @default.
• W2029726082 hasRelatedWork W4226417502 @default.
• W2029726082 isParatext "false" @default.
• W2029726082 isRetracted "false" @default.

• next