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- W2029734559 abstract "Significance Epstein–Barr virus establishes a life-long latent infection (i.e., no virus is produced) in B cells in most people worldwide. A specific group of latency-associated proteins is expressed in B-cell and epithelial malignancies and likely contributes to tumorigenesis, but the role of epithelial cells in the virus life cycle is not well understood. We grew epithelial cells in organotypic cultures, allowing the cells to differentiate and stratify as they do in vivo. Unlike B-cell infection, EBV infection of epithelial cultures resulted in spontaneous production of high levels of virus, likely expanding the virus pool and increasing efficiency of transmission. This model of EBV-infected epithelium will enhance our understanding of the role of epithelial cells in the EBV life cycle." @default.
- W2029734559 created "2016-06-24" @default.
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- W2029734559 date "2014-10-13" @default.
- W2029734559 modified "2023-10-11" @default.
- W2029734559 title "Efficient replication of Epstein–Barr virus in stratified epithelium in vitro" @default.
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- W2029734559 doi "https://doi.org/10.1073/pnas.1400818111" @default.
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