FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029770593> ?p ?o ?g. }

• W2029770593 endingPage "e426" @default.
• W2029770593 startingPage "e426" @default.
• W2029770593 abstract "Neuropathic pain is a well-known type of chronic pain caused by damage to the nervous system. Until recently, many researchers have primarily focused on identifying cellular or chemical sources of neuropathic pain or have approached neuropathic pain via the basis of biological study. We investigated whether both mmu-mir-23b (miR23b) and NADPH oxidase 4 (NOX4) antibody infusion can alleviate neuropathic pain by compensating for abnormally downregulated miR23b via reducing the expression of its target gene, NOX4, a reactive oxygen species (ROS) family member overexpressed in neuropathic pain. Ectopic miR23b expression effectively downregulated NOX4 and finally normalized glutamic acid decarboxylase 65/67 expression. Moreover, animals with neuropathic pain showed significantly improved paw withdrawal thresholds (PWTs) following miR23b infusion. Normalizing miR23b expression in tissue lesions, caused by neuropathic pain induction, reduced inflammatory mediators and increased several ROS scavengers. Moreover, γ-aminobutyric acid (GABA)ergic neurons coexpressed suboptimal levels of miR23b and elevated NOX4/ROS after pain induction at the cellular level. MiR23b finally protects GABAergic neurons against ROS/p38/c-Jun N-terminal kinase (JNK)-mediated apoptotic death. By evaluating the functional behavior of mice receiving pain/miR23b, normal/anti-miR23b, anti-miR23b/si-NOX4, pain/NOX4 antibody, pain/ascorbic acid, and pain/ascorbic acid/NOX4 antibody, the positive role of miR23b and the negative role of NOX4 in neuropathic pain were confirmed. Based on this study, we conclude that miR23b has a crucial role in the amelioration of neuropathic pain in injured spinal cord by inactivating its target gene, NOX4, and protection of GABAergic neurons from cell death. We finally suggest that infusion of miR23b and NOX4 antibody may provide attractive diagnostic and therapeutic resources for effective pain modulation in neuropathic pain." @default.
• W2029770593 created "2016-06-24" @default.
• W2029770593 creator A5009439380 @default.
• W2029770593 creator A5026652346 @default.
• W2029770593 creator A5041179704 @default.
• W2029770593 creator A5066509068 @default.
• W2029770593 creator A5074528076 @default.
• W2029770593 creator A5087162552 @default.
• W2029770593 date "2012-11-15" @default.
• W2029770593 modified "2023-10-08" @default.
• W2029770593 title "Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord" @default.
• W2029770593 cites W1738040396 @default.
• W2029770593 cites W1965820028 @default.
• W2029770593 cites W1968186617 @default.
• W2029770593 cites W1976295332 @default.
• W2029770593 cites W1989344978 @default.
• W2029770593 cites W1990967370 @default.
• W2029770593 cites W1999085114 @default.
• W2029770593 cites W2002510458 @default.
• W2029770593 cites W2006078892 @default.
• W2029770593 cites W2008175324 @default.
• W2029770593 cites W2010578760 @default.
• W2029770593 cites W2016448869 @default.
• W2029770593 cites W2025384240 @default.
• W2029770593 cites W2030724012 @default.
• W2029770593 cites W2040088974 @default.
• W2029770593 cites W2042380144 @default.
• W2029770593 cites W2046023535 @default.
• W2029770593 cites W2051403674 @default.
• W2029770593 cites W2052133685 @default.
• W2029770593 cites W2055197670 @default.
• W2029770593 cites W2058200273 @default.
• W2029770593 cites W2060515857 @default.
• W2029770593 cites W2060569438 @default.
• W2029770593 cites W2069977126 @default.
• W2029770593 cites W2072044677 @default.
• W2029770593 cites W2076419837 @default.
• W2029770593 cites W2076919372 @default.
• W2029770593 cites W2077864446 @default.
• W2029770593 cites W2081480634 @default.
• W2029770593 cites W2085799997 @default.
• W2029770593 cites W2098586449 @default.
• W2029770593 cites W2103577428 @default.
• W2029770593 cites W2111964682 @default.
• W2029770593 cites W2116641097 @default.
• W2029770593 cites W2124105819 @default.
• W2029770593 cites W2139081697 @default.
• W2029770593 cites W2148030708 @default.
• W2029770593 cites W2148908080 @default.
• W2029770593 cites W2161226217 @default.
• W2029770593 cites W2162730620 @default.
• W2029770593 cites W2331299494 @default.
• W2029770593 doi "https://doi.org/10.1038/cddis.2012.168" @default.
• W2029770593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3542604" @default.
• W2029770593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23152062" @default.
• W2029770593 hasPublicationYear "2012" @default.
• W2029770593 type Work @default.
• W2029770593 sameAs 2029770593 @default.
• W2029770593 citedByCount "63" @default.
• W2029770593 countsByYear W20297705932013 @default.
• W2029770593 countsByYear W20297705932014 @default.
• W2029770593 countsByYear W20297705932015 @default.
• W2029770593 countsByYear W20297705932016 @default.
• W2029770593 countsByYear W20297705932017 @default.
• W2029770593 countsByYear W20297705932018 @default.
• W2029770593 countsByYear W20297705932019 @default.
• W2029770593 countsByYear W20297705932020 @default.
• W2029770593 countsByYear W20297705932021 @default.
• W2029770593 countsByYear W20297705932022 @default.
• W2029770593 countsByYear W20297705932023 @default.
• W2029770593 crossrefType "journal-article" @default.
• W2029770593 hasAuthorship W2029770593A5009439380 @default.
• W2029770593 hasAuthorship W2029770593A5026652346 @default.
• W2029770593 hasAuthorship W2029770593A5041179704 @default.
• W2029770593 hasAuthorship W2029770593A5066509068 @default.
• W2029770593 hasAuthorship W2029770593A5074528076 @default.
• W2029770593 hasAuthorship W2029770593A5087162552 @default.
• W2029770593 hasBestOaLocation W20297705931 @default.
• W2029770593 hasConcept C118552586 @default.
• W2029770593 hasConcept C126322002 @default.
• W2029770593 hasConcept C170493617 @default.
• W2029770593 hasConcept C181199279 @default.
• W2029770593 hasConcept C2776151105 @default.
• W2029770593 hasConcept C2777107010 @default.
• W2029770593 hasConcept C2778334475 @default.
• W2029770593 hasConcept C2779177108 @default.
• W2029770593 hasConcept C2779719074 @default.
• W2029770593 hasConcept C2779765511 @default.
• W2029770593 hasConcept C2780775167 @default.
• W2029770593 hasConcept C2986274086 @default.
• W2029770593 hasConcept C31903555 @default.
• W2029770593 hasConcept C42219234 @default.
• W2029770593 hasConcept C55493867 @default.
• W2029770593 hasConcept C71924100 @default.
• W2029770593 hasConcept C86803240 @default.
• W2029770593 hasConcept C9497952 @default.
• W2029770593 hasConcept C98274493 @default.
• W2029770593 hasConceptScore W2029770593C118552586 @default.

• next