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• W2029774225 abstract "Purpose of review To give an overview of the recent research into whether a lack of vitamin D contributes to the development of atopy and asthma in childhood. Recent findings I describe here the recent epidemiological studies relating vitamin D status to atopy and asthma in children, focusing on determinants of major asthma phenotypes in childhood. Recent findings include the observations that vitamin D levels are inversely associated with degree of corticosteroid use, worsening airflow limitation and increased exacerbations among asthmatics. Low vitamin D has been associated with atopy and asthma in children and adolescents in a community cohort, predominantly in boys, with vitamin D at age 6 predicting these outcomes at 14. I also detail the mechanistic studies examining relevant vitamin D-regulated processes; recent findings include the demonstration that offspring of mice with vitamin D deficiency in pregnancy show reduced lung volume and function. Summary The current literature suggests that intervention to ensure adequate vitamin D levels during both pregnancy and childhood may reduce the development of atopy and asthma in children. However, important questions need to be answered regarding the levels of vitamin D required, which may vary between the sexes and between individuals, and the optimal timing and duration of such intervention." @default.
• W2029774225 created "2016-06-24" @default.
• W2029774225 creator A5082721735 @default.
• W2029774225 date "2012-06-01" @default.
• W2029774225 modified "2023-10-03" @default.
• W2029774225 title "Vitamin D and atopy and asthma phenotypes in children" @default.
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• W2029774225 doi "https://doi.org/10.1097/aci.0b013e3283534a32" @default.
• W2029774225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22475998" @default.
• W2029774225 hasPublicationYear "2012" @default.
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