Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029777533> ?p ?o ?g. }
- W2029777533 endingPage "573" @default.
- W2029777533 startingPage "567" @default.
- W2029777533 abstract "The role of hyper-gastrinaemia in the incidence of colonic cancer remains to be clarified. The aim of this study was to determine whether cholecystokinin-2 (CCK-2) receptor expression predicts the sensitivity of human colonic adenomas to the proliferative effects of serum hyper-gastrinaemia. Gene expression of the classical (74 kDa) CCK-2 receptor in human colonic adenoma specimens and cell lines, was quantified by real-time PCR. Western blotting, using a CCK-2 receptor antiserum, confirmed protein expression. A transformed human colonic adenoma was grown in SCID mice, with hyper-gastrinaemia induced by protein pump inhibitors. CCK-2 receptor blockade was achieved by using neutralising antiserum. Both human colonic adenoma cell lines and biopsies expressed CCK-2 receptor mRNA at levels comparable with CCK-2 receptor transfected fibroblasts and oxyntic mucosa. Western blotting confirmed immunoreactive CCK-2 receptor bands localised to 45, 74 and 82.5 kDa. Omeprazole and lansoprazole-induced hyper-gastrinaemia (resulting in serum gastrin levels of 34.0 and 153.0 pM, respectively) significantly increased the weight of the human adenoma grafts (43% (P=0.016) and 70% (P=0.014), respectively). The effect of hypergastrinaemia on tumour growth was reversed by use of antiserum directed against the CCK-2 receptor. Hyper-gastrinaemia may promote proliferation of human colonic adenomas that express CCK-2 receptor isoforms." @default.
- W2029777533 created "2016-06-24" @default.
- W2029777533 creator A5002262131 @default.
- W2029777533 creator A5047130149 @default.
- W2029777533 creator A5071293774 @default.
- W2029777533 creator A5072254993 @default.
- W2029777533 creator A5072709323 @default.
- W2029777533 creator A5083720978 @default.
- W2029777533 creator A5089628157 @default.
- W2029777533 date "2002-08-01" @default.
- W2029777533 modified "2023-10-11" @default.
- W2029777533 title "Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence" @default.
- W2029777533 cites W1517156830 @default.
- W2029777533 cites W1874353661 @default.
- W2029777533 cites W1964147298 @default.
- W2029777533 cites W1965831951 @default.
- W2029777533 cites W1968120005 @default.
- W2029777533 cites W1970266578 @default.
- W2029777533 cites W1979529504 @default.
- W2029777533 cites W1984415406 @default.
- W2029777533 cites W1984647532 @default.
- W2029777533 cites W1994529404 @default.
- W2029777533 cites W2001996450 @default.
- W2029777533 cites W2002208228 @default.
- W2029777533 cites W2006215799 @default.
- W2029777533 cites W2011995387 @default.
- W2029777533 cites W2022938510 @default.
- W2029777533 cites W2029989332 @default.
- W2029777533 cites W2036704039 @default.
- W2029777533 cites W2038638980 @default.
- W2029777533 cites W2041579504 @default.
- W2029777533 cites W2052128811 @default.
- W2029777533 cites W2052480040 @default.
- W2029777533 cites W2079293191 @default.
- W2029777533 cites W2092590272 @default.
- W2029777533 cites W2098738631 @default.
- W2029777533 cites W2104808348 @default.
- W2029777533 cites W2111417076 @default.
- W2029777533 cites W2112991983 @default.
- W2029777533 cites W2114213874 @default.
- W2029777533 cites W2117213772 @default.
- W2029777533 cites W2117884342 @default.
- W2029777533 cites W2119705368 @default.
- W2029777533 cites W2124604698 @default.
- W2029777533 cites W2139610417 @default.
- W2029777533 cites W2151377836 @default.
- W2029777533 cites W2171376739 @default.
- W2029777533 cites W2237552215 @default.
- W2029777533 cites W2282618588 @default.
- W2029777533 cites W2591775790 @default.
- W2029777533 cites W4251293905 @default.
- W2029777533 cites W1761182664 @default.
- W2029777533 doi "https://doi.org/10.1038/sj.bjc.6600509" @default.
- W2029777533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2376163" @default.
- W2029777533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12189558" @default.
- W2029777533 hasPublicationYear "2002" @default.
- W2029777533 type Work @default.
- W2029777533 sameAs 2029777533 @default.
- W2029777533 citedByCount "43" @default.
- W2029777533 countsByYear W20297775332012 @default.
- W2029777533 countsByYear W20297775332015 @default.
- W2029777533 countsByYear W20297775332016 @default.
- W2029777533 countsByYear W20297775332017 @default.
- W2029777533 countsByYear W20297775332018 @default.
- W2029777533 countsByYear W20297775332019 @default.
- W2029777533 countsByYear W20297775332020 @default.
- W2029777533 countsByYear W20297775332021 @default.
- W2029777533 countsByYear W20297775332022 @default.
- W2029777533 countsByYear W20297775332023 @default.
- W2029777533 crossrefType "journal-article" @default.
- W2029777533 hasAuthorship W2029777533A5002262131 @default.
- W2029777533 hasAuthorship W2029777533A5047130149 @default.
- W2029777533 hasAuthorship W2029777533A5071293774 @default.
- W2029777533 hasAuthorship W2029777533A5072254993 @default.
- W2029777533 hasAuthorship W2029777533A5072709323 @default.
- W2029777533 hasAuthorship W2029777533A5083720978 @default.
- W2029777533 hasAuthorship W2029777533A5089628157 @default.
- W2029777533 hasBestOaLocation W20297775331 @default.
- W2029777533 hasConcept C107539642 @default.
- W2029777533 hasConcept C126322002 @default.
- W2029777533 hasConcept C134018914 @default.
- W2029777533 hasConcept C153911025 @default.
- W2029777533 hasConcept C170493617 @default.
- W2029777533 hasConcept C2776986829 @default.
- W2029777533 hasConcept C2777428134 @default.
- W2029777533 hasConcept C2777593968 @default.
- W2029777533 hasConcept C32110497 @default.
- W2029777533 hasConcept C49039625 @default.
- W2029777533 hasConcept C71924100 @default.
- W2029777533 hasConcept C86803240 @default.
- W2029777533 hasConceptScore W2029777533C107539642 @default.
- W2029777533 hasConceptScore W2029777533C126322002 @default.
- W2029777533 hasConceptScore W2029777533C134018914 @default.
- W2029777533 hasConceptScore W2029777533C153911025 @default.
- W2029777533 hasConceptScore W2029777533C170493617 @default.
- W2029777533 hasConceptScore W2029777533C2776986829 @default.
- W2029777533 hasConceptScore W2029777533C2777428134 @default.
- W2029777533 hasConceptScore W2029777533C2777593968 @default.