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- W2029779786 abstract "The acute and chronic effects of bilateral lesions of the substantia nigra upon amphetamine- and apomorphine-induced stereotyped behaviour and its modification by haloperidol and arecoline were studied in the rat. A mild spontaneous stereotyped behaviour was observed during the acute stage following the induction of nigral lesions. In order to inhibit this stereotypy a 20- to 25-fold increase in the normal antistereotypic dose of haloperidol and large increases in the dose of arecoline were required. Amphetamine, which was shown to induce a dose-dependent stereotypy in normal rats, increased the intensity of the spontaneous stereotypy but the effects were slightly less than additive. In contrast, the effects of apomorphine, which was also shown to induce a dose-dependent stereotypy in normal rats, were markedly reduced during this acute stage. Although no significant modification of amphetamine stereotypy was apparent at the chronic stage, the ability of apomorphine to induce a stereotyped behaviour was virtually abolished. The dose-dependent inhibitory effects of haloperidol and arecoline upon amphetamine or apomorphine stereotypy were not significantly modified during the acute or chronic stages after the lesions. Results indicate the non-essential nature of the pars compacta of the substantia nigra and, therefore, the postulated dopaminergic nigro-striatal pathway, for amphetamine stereotypy, and suggest that apomorphine stereotypy is not mediated via a direct action upon the dopamine receptor, but requires an effective nigro-striatal dopaminergic system. Also, it would appear that the mechanism involved in spontaneous stereotypy are not the same as those of the drug-induced state." @default.
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- W2029779786 date "1972-04-01" @default.
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- W2029779786 title "The substantia nigra and stereotyped behaviour" @default.
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- W2029779786 doi "https://doi.org/10.1016/0014-2999(72)90136-7" @default.
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